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SARS-COV-2 LINEAGES AND SUB-LINEAGES CIRCULATING WORLDWIDE: A DYNAMIC OVERVIEW
Author
Affilliation
Burnett School of Biomedical Sciences, University of Central Florida. Orlando, FL, USA.
Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland. Baltimore, MD, USA.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.
National HIV/AIDS ResearhCenter, Istituto Superiore di Sanità. Rome, Italy.
Cardiovascular-Respiratory Sciences Department, Sant’ Andrea Hospital-Sapienza Università. Rome, Italy.
Dipartimento di Scienze Biochimiche e Centro di Biologia Molecolare del Consiglio Nazionale delle Ricerche, Università La Sapienza. Roma, Italy.
Department of Biochemical Sciences “A. Rossi Fanelli,” University of Rome “La Sapienza,”. Rome, Italy.
Dipartimento di Salute Pubblica e Malattie Infettive, Policlinico Umberto I Università “Sapienza,”. Rome, Italy.
Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland. Baltimore, MD, USA.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte. MG, Brasil.
Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland. Baltimore, MD, USA.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.
National HIV/AIDS ResearhCenter, Istituto Superiore di Sanità. Rome, Italy.
Cardiovascular-Respiratory Sciences Department, Sant’ Andrea Hospital-Sapienza Università. Rome, Italy.
Dipartimento di Scienze Biochimiche e Centro di Biologia Molecolare del Consiglio Nazionale delle Ricerche, Università La Sapienza. Roma, Italy.
Department of Biochemical Sciences “A. Rossi Fanelli,” University of Rome “La Sapienza,”. Rome, Italy.
Dipartimento di Salute Pubblica e Malattie Infettive, Policlinico Umberto I Università “Sapienza,”. Rome, Italy.
Institute of Human Virology, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland. Baltimore, MD, USA.
Medical Statistic and Molecular Epidemiology Unit, University of Biomedical Campus. Rome, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte. MG, Brasil.
Abstract
Background: Severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) originated in Wuhan, China, in early December
2019 has rapidly widespread worldwide, becoming
one of the major global public health issues of the last centuries.
Key Messages: Over the course of the pandemic, due
to the advanced whole-genome sequencing technologies,
an unprecedented amount of genomes have been generated,
providing invaluable insights into the ongoing evolution
and epidemiology of the virus during the pandemic Therefore, this large amount of data played an important
role in the SARS-CoV-2 mitigation and control strategies. Key
Messages: The active monitoring and characterization of
the SARS-CoV-2 lineages circulating worldwide is useful for
a more specific diagnosis, better care, and timely treatment.
In this review, a concise characterization of all the lineages
and sub-lineages circulating and co-circulating across the
world has been presented in order to determine the magnitude
of the SARS-CoV-2 threat and to better understand the
virus genetic diversity and its dispersion dynamics.
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