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UPDATE ON THE PHYLODYNAMICS OF SADS-COV
Epidemiologia
Diversidade genética
Filodinâmica
Alfacoronavírus
Autor
Afiliación
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy / Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.
Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy,
National Reference Laboratory of HIV, National Center of Infectious and Parasitic Diseases. 1504 Sofia, Bulgaria.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.
Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy / Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.
Istituto Zooprofilattico Sperimentale della Sardegna, 07100 Sassari, Italy,
National Reference Laboratory of HIV, National Center of Infectious and Parasitic Diseases. 1504 Sofia, Bulgaria.
Department of Veterinary Medicine, University of Sassari. 07100 Sassari, Italy.
Department of Biomedical Sciences, University of Sassari. 07100 Sassari, Italy.
Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome. 00128 Rome, Italy.
Resumen en ingles
Coronaviruses are known to be harmful and heterogeneous viruses, able to infect a large
number of hosts. Among them, SADS-CoV (Swine Acute Diarrhea Syndrome Coronavirus), also
known as PEAV (Porcine Enteric Alphacoronavirus), or SeA-CoV (Swine Enteric Alphacoronavirus),
is the most recent Alphacoronavirus discovered, and caused several outbreaks reported in Chinese
swine herds between late 2016 and 2019. We performed an upgraded phylodinamic reconstruction
of SADS-CoV based on all whole genomes available on 21 June 2021. Results showed a very
close relationship between SADS-CoV and HKU2-like CoV, which may represent the evolutionary
intermediate step towards the present SADS-CoV. The direct progenitor of SADS-CoV is so far
unknown and, although it is well known that horseshoe bats are reservoirs for Rhinolophus bat
coronavirus HKU2-like (HKU2-like CoVs), the transmission path from bats to pigs is still unclear. The
discrepancies in the phylogenetic position of rodent CoV, when different molecular markers were
considered, corroborate the recombination hypothesis, suggesting that wild rats, which are frequent
in farms, may have played a key role. The failure of the attempt at molecular dating, due to the lack
of a clock signal, also corroborates the occurrence of a recombination event hypothesis. Zoonotic
infections originating in wildlife can easily become a significant threat for human health. In such
a context, due to the high recombination and cross-species capabilities of Coronavirus, SADS-CoV
represents a possible high-risk pathogen for humans which needs a constant molecular monitoring.
Palabras clave en portugues
CoronavírusEpidemiologia
Diversidade genética
Filodinâmica
Alfacoronavírus
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