Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/51329
Tipo
ArtículoDerechos de autor
Acceso restringido
Colecciones
Metadatos
Mostrar el registro completo del ítem
PHENOTYPIC FEATURES OF INNATE AND ADAPTIVE IMMUNITY IN PATIENTS WITH CHRONIC HEPATITIS C AND END-STAGE RENAL DISEASE
RT-PCR
canine diseases
visceral leishmaniasis
Leishmania chagasi
Autor
Afiliación
Universidade Federal de Juiz de Fora. Hospital Universitario. Serviço de Gastroenterologia. Juiz de Fora, MG, Brazil
Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil
Universidade Federal de Juiz de Fora. Hospital Universitario. Serviço de Gastroenterologia. Juiz de Fora, MG, Brazil
Núcleo de Nefrologia de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Hospital das Clınicas. Instituto Alfa de Gastroenterologia. Departamento de Clınica Medica. Belo Horizonte, MG, Brazil
Universidade Federal de Juiz de Fora. Hospital Universitario. Serviço de Gastroenterologia. Juiz de Fora, MG, Brazil
Núcleo de Nefrologia de Belo Horizonte. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro Pesquisas Rene Rachou. Belo Horizonte, MG, Brazil
Resumen en portugues
Background: The knowledge of the immunological profile of patients with chronic hepatitis C (CHC) and end-stage renal disease (ESRD) on haemodialysis (HD) is still limited.
Aims: This study investigated the immune response profile in HCV patients with concomitant ESRD focusing on the influence of the renal disease on the phenotypic profile of peripheral blood lymphocytes.
Methods: Immunophenotypic features of peripheral blood leucocytes were assessed by flow cytometry in two distinct groups: HCV patients with ESRD (CHC+ESRD, n = 16) and HCV patients with normal renal function (CHC, n = 20). Two control groups that were included were as follows: HCV negative blood donors (BD, n = 15) and HCV negative patients with ESRD (ESRD, n = 19).
Results: Higher frequency of macrophage-like and pro-inflammatory monocytes along with enhanced frequency of CD3(-) CD16(-) CD56(+) , mainly CD56(dim) NK-cells, were the hallmark of CHC+ESRD patients. Lower frequency of B cells with significant decreased of B1 and CD23(+) B-cells were associated with ESRD, regardless the HCV infection. Although higher rates of activated CD4(+) and CD8(+) T cells were observed in the CHC and CHC+ESRD groups, the chemotaxis of T-cell subsets, based on their chemokine receptor expression, was affected by ESRD.
Conclusions: Chronic hepatitis C patients with ESRD on HD exhibit distinctive phenotypic profile of circulating leucocytes. It may be implicated in the natural history of HCV infection in this particular group of patients and warrants further investigation.
Palabras clave en portugues
cytokinesRT-PCR
canine diseases
visceral leishmaniasis
Leishmania chagasi
Compartir