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https://www.arca.fiocruz.br/handle/icict/51041
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2024
Coleções
- IOC - Artigos de Periódicos [12596]
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LIPID DROPLETS DIVERSITY AND FUNCTIONS IN INFLAMMATION AND IMMUNE RESPONSE
Metabolismo lipídico
Inflamação
Gotículas de lipídios
Proteoma de organela
Eicosanóides
Interação de organelas
Inflammation
Lipid droplets
Organelle proteome
Eicosanoids
Organelle interaction
Immunometabolism
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Introduction: Lipid droplets (LDs) are dynamic and evolutionary conserved lipid-enriched organelles
composed of a core of neutral lipids surrounded by a monolayer of phospholipids associated with
a diverse array of proteins that are cell- and stimulus-regulated. Far beyond being simply a deposit of
neutral lipids, accumulating evidence demonstrate that LDs act as spatial and temporal local for lipid
and protein compartmentalization and signaling organization.
Areas covered: This review focuses on the progress in our understanding of LD protein diversity and
LD functions in the context of cell signaling and immune responses, highlighting the relationship
between LD composition with the multiple roles of this organelle in immunometabolism, inflammation
and host-response to infection.
Expert opinion: LDs are essential platforms for various cellular processes, including metabolic regulation,
cell signaling, and immune responses. The functions of LD in infection and inflammatory disease
are associated with the dynamic and complexity of their proteome. Our contemporary view place LDs
as critical regulators of different inflammatory and infectious diseases and key markers of leukocyte
activation.
Palavras-chave
ImunometabolismoMetabolismo lipídico
Inflamação
Gotículas de lipídios
Proteoma de organela
Eicosanóides
Interação de organelas
Palavras-chave em inglês
Lipid metabolismInflammation
Lipid droplets
Organelle proteome
Eicosanoids
Organelle interaction
Immunometabolism
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