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Objetivos de Desarrollo Sostenible
03 Saúde e Bem-EstarColecciones
- INI - Artigos de Periódicos [3488]
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WORLD HEALTH ORGANIZATION EXPERT WORKING GROUP: RECOMMENDATIONS FOR ASSESSING MORBIDITY ASSOCIATED WITH ENTERIC PATHOGENS
Autor
Hasso-Agopsowicz, Mateusz
Lopman, Benjamin A.
Lanata, Claudio F.
McQuade, Elizabeth T. Rogawski
Kang, Gagandeep
Prudden, Holly J.
Khalil, Ibrahim
Platts-Mills, James A .
Kotloff, Karen
Jit, Mark
Riddle, Mark S.
Pavlinac, Patricia B.
Luz, Paula M.
Pitzer, Virginia E.
Breiman, Robert F.
Giersing, Birgitte K.
Lopman, Benjamin A.
Lanata, Claudio F.
McQuade, Elizabeth T. Rogawski
Kang, Gagandeep
Prudden, Holly J.
Khalil, Ibrahim
Platts-Mills, James A .
Kotloff, Karen
Jit, Mark
Riddle, Mark S.
Pavlinac, Patricia B.
Luz, Paula M.
Pitzer, Virginia E.
Breiman, Robert F.
Giersing, Birgitte K.
Afiliación
World Health Organization. Geneva, Switzerland.
Emory University. Atlanta, United States.
Nutritional Research Institute. Lima, Peru.
Emory University. Atlanta, United States.
Christian Medical College. Vellore, India.
Independent Consultant. United Kingdom.
University of Washington. Seattle, United States.
University of Virginia. Charlottesville, United States.
University of Maryland. College Park, United States.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
University of Nevada. Reno, United States.
University of Washington. Seattle, United States.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Yale University. United States.
Emory University. Atlanta, United States.
World Health Organization. Geneva, Switzerland.
Emory University. Atlanta, United States.
Nutritional Research Institute. Lima, Peru.
Emory University. Atlanta, United States.
Christian Medical College. Vellore, India.
Independent Consultant. United Kingdom.
University of Washington. Seattle, United States.
University of Virginia. Charlottesville, United States.
University of Maryland. College Park, United States.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
University of Nevada. Reno, United States.
University of Washington. Seattle, United States.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Yale University. United States.
Emory University. Atlanta, United States.
World Health Organization. Geneva, Switzerland.
Resumen en ingles
Background: Diarrhoeal infections are one of the leading causes of child's mortality and morbidity. Vaccines against Shigella, enterotoxigenic E. coli (ETEC), norovirus and invasive non-typhoidal Salmonella are in clinical development, however, their full value in terms of short and long-term health and socio-economic burden needs to be evaluated and communicated, to rationalise investment in vaccine development, and deployment. While estimates of mortality of enteric infections exist, the long-term morbidity estimates are scarce and have not been systematically collected.
Methods: The World Health Organization (WHO) has convened a Burden of Enteric Diseases Morbidity Working Group (BoED MWG) who identified key workstreams needed to characterise the morbidity burden of enteric infections. The group also identified four criteria for the prioritisation of pathogens of which impact on long-term morbidity needs to be assessed.
Results: The BoED MWG suggested to identify and analyse the individual level data from historical datasets to estimate the impact of enteric infections and confounders on long-term morbidity, including growth faltering and cognitive impairment in children (workstream 1); to conduct a systematic review of evidence on the association of aetiology specific diarrhoea with short- and long- term impact on growth, including stunting, and possibly cognitive impairment in children, while accounting for potential confounders (workstream 2); and to conduct a systematic review of evidence on the association of aetiology specific diarrhoea with short- and long- term impact on health outcomes in adults. The experts prioritised four pathogens for this work: Campylobacter jejuni, ETEC (LT or ST), norovirus (G1 or G2), and Shigella (dysenteriae, flexneri, sonnei).
Conclusions: The proposed work will contribute to improving the understanding of the impact of enteric pathogens on long-term morbidity. The timing of this work is critical as all four pathogens have vaccine candidates in the clinical pipeline and decisions about investments in development, manufacturing or vaccine procurement and use are expected to be made soon.
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