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https://www.arca.fiocruz.br/handle/icict/49113
CONGENITAL ZIKA SYNDROME: GROWTH, CLINICAL, AND MOTOR DEVELOPMENT OUTCOMES UP TO 36 MONTHS OF AGE AND DIFFERENCES ACCORDING TO MICROCEPHALY AT BIRTH
Autor(es)
Cavalcante, Tamires Barradas
Ribeiro, Marizélia Rodrigues Costa
Sousa, Patrícia da Silva
Costa, Elaine de Paula Fiod
Alves, Maria Teresa Seabra Soares de Brito e
Simões, Vanda Maria Ferreira
Batista, Rosângela Fernandes Lucena
Takahasi, Eliana Harumi Morioka
Amaral, Gláucio Andrade
Khouri, Ricardo
Branco, Maria dos Remédios Freitas Carvalho
Mendes, Ana Karolina Torres
Costa, Luciana Cavalcante
Campos, Marcos Adriano Garcia
Silva, Antônio Augusto Moura da
Ribeiro, Marizélia Rodrigues Costa
Sousa, Patrícia da Silva
Costa, Elaine de Paula Fiod
Alves, Maria Teresa Seabra Soares de Brito e
Simões, Vanda Maria Ferreira
Batista, Rosângela Fernandes Lucena
Takahasi, Eliana Harumi Morioka
Amaral, Gláucio Andrade
Khouri, Ricardo
Branco, Maria dos Remédios Freitas Carvalho
Mendes, Ana Karolina Torres
Costa, Luciana Cavalcante
Campos, Marcos Adriano Garcia
Silva, Antônio Augusto Moura da
Afiliação
“Múltipla – ver em notas”
Resumo em Inglês
Little is known regarding the developmental consequences of congenital Zika syndrome
(CZS) without microcephaly at birth. Most previously published clinical series were descriptive and they
had small sample sizes.
Study design: We conducted a cohort study to compare the growth, clinical, and motor development
outcomes for 110 children with CZS born with and without microcephaly up to their third birthday.
Ninety-three had their head circumference (HC) at birth abstracted and they did not have hypertensive
hydrocephalus at birth, where 61 were born with microcephaly and 32 without.
Results: The HC z-scores decreased steeply from birth to six months of age, i.e., from –3.77 to –6.39 among
those with microcephaly at birth and from –1.03 to –3.84 among those without. Thus, at 6 months of age,
the mean HC z-scores for children born without microcephaly were nearly the same as those for children
born with microcephaly. Children born without microcephaly were less likely to have brain damage,
ophthalmic abnormalities, and drug-resistant epilepsy, but the differences in many conditions were not
statistically significant.
Conclusions: Children born without microcephaly were only slightly less likely to present severe
neurologic impairment and to develop postnatal-onset microcephaly, and some of the original
differences between the groups tended to dissipate with age.
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