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- BA - IGM - Preprint [90]
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IMPACT OF HIV STATUS ON SYSTEMIC INFLAMMATION DURING PREGNANCY RUNNING HEAD: INFLAMMATION IN PREGNANT WOMEN WITH HIV
Autor
Afiliación
“Múltipla – ver em notas”
Resumen en ingles
There are limited studies on the «association» of «HIV infection» with systemic
«inflammation» during «pregnancy».
Design: A «cohort study» (N=220) of «pregnant women» with «HIV» (N=70) (all on antiretroviral
«therapy») and without «HIV» (N=150) were enrolled from an antenatal clinic in Pune, «India».
«Methods»: The following systemic inflammatory markers were measured in «plasma» samples
using «immunoassays»: soluble CD163 (sCD163), «soluble CD14» («sCD14»), intestinal fatty acidbinding
«protein» (I-FABP), «C-reactive protein» (CRP), «alpha 1-acid glycoprotein» (AGP),
«interferon»-β (IFNβ), «interferon»-γ (IFNγ), «interleukin» (IL)-1β, «IL-6», «IL-13», «IL-17A» and «tumor»
«necrosis» factor α (TNFα). Generalized estimating equation (GEE) and «linear regression»
models were used to assess the «association» of «HIV» status with each inflammatory marker
during «pregnancy» and by trimester, respectively.
Results: «Pregnant women» with «HIV» had higher levels of markers for gut «barrier» dysfunction
(I-FABP), «monocyte» activation («sCD14») and markers of systemic «inflammation» («IL-6» and
TNFα), but surprisingly lower levels of AGP, an «acute phase protein», compared to pregnant
«women» without «HIV», with some trimester-specific differences.
Conclusions: Our data show that «women» with «HIV» had higher levels of markers of gut
«barrier» dysfunction, «monocyte» activation and systemic «inflammation». These markers, some of
which are associated with «preterm birth», might help explain the increase in adverse «birth»
outcomes in «women» with «HIV» and could suggest targets for potential interventions.
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