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https://www.arca.fiocruz.br/handle/icict/48696
DISTRIBUTION OF HLA-DRB1 ALLELES IN BRICS COUNTRIES WITH A HIGH TUBERCULOSIS BURDEN: A SYSTEMATIC REVIEW AND META-ANALYSIS
Vacinas
Mycobacterium bovis
Antígenos HLA
Histocompatibilidade
Imunogenicidade da Vacina
Cadeias HLA-DRB1
Epitope-based vaccine
Rational vaccine design
Vaccine candidate
Major histocompatibility complex
Immunogenicity
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Rede Brasileira de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Introduction: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world’s TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Promising antigen-based vaccines have been proposed as prophylactic
and/or immunotherapeutic approaches to boost BCG vaccination. Relevant antigens must interact with the range of human leukocyte antigen (HLA) molecules present in target populations; yet this information is currently not available. Methods: MEDLINE and EMBASE were systematically searched for articles published during 2013-2020 to measure the allelic frequencies of HLA-DRB1 in the BRICS. Results: In total, 67 articles involving 3,207,861 healthy individuals were included in the meta-analysis. HLA-DRB1 alleles
*03, *04, *07, *11, *13, and *15 were consistently identified at high frequencies across the BRICS, with a combined estimated frequency varying from 52% to 80%. HLA-DRB1 alleles *01, *08, *09, *10, *12, and *14 were found to be relevant in only one or two BRICS populations. Conclusions: By combining these alleles, it is possible to ensure at least 80% coverage throughout the BRICS populations.
Palavras-chave
TuberculoseVacinas
Mycobacterium bovis
Antígenos HLA
Histocompatibilidade
Imunogenicidade da Vacina
Cadeias HLA-DRB1
Palavras-chave em inglês
TuberculosisEpitope-based vaccine
Rational vaccine design
Vaccine candidate
Major histocompatibility complex
Immunogenicity
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