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SARS-COV-2 VARIANT OF CONCERN P.1 (GAMMA) INFECTION IN YOUNG AND MIDDLE-AGED PATIENTS ADMITTED TO THE INTENSIVE CARE UNITS OF A SINGLE HOSPITAL IN SALVADOR, NORTHEAST BRAZIL, FEBRUARY 2021 (PREPRINT)
SARS-CoV-2
Unidades de Terapia Intensiva
Pandemia
Rede Genômica Fiocruz
GENOMAHCOV
https://www.arca.fiocruz.br/handle/icict/50679
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Resumen en ingles
To evaluate changes in COVID-19 patients' characteristics occurring after the emergence of the SARS-CoV-2 variant of concern (VOC) P.1 (Gamma) by comparing the clinical, demographic and laboratory profile of patients hospitalized during the first (May-July 2020) and second (December 2020 - February 2021) pandemic waves. Methods: Data was collected from records of COVID-19 patients (n=4164) admitted to a single hospital in Salvador, Northeast Brazil. SARS-CoV-2 genome sequencing was performed in nasopharyngeal swab samples from 12 patients with age < 60 years-old admitted to the intensive care units (ICU) in February 2021. Results: From June 2020 to February 2021, the median age of patients admitted in the ICU decreased from 66 to 58 years (p<0.05), accompanied by an increased proportion of patients without comorbidities (15.32% vs 32.20%, p<0.0001). A significant reduction in the Ct values of SARS-CoV-2 RT-PCR tests was observed in the second wave (p<0.0001). Sequencing analysis detected lineage Gamma in all 12 ICU patients sampled in February 2021. Conclusion: Our results demonstrated an increased proportion of younger adults without comorbidities with severe disease during the second COVID-19 wave, shortly after the confirmation of local Gamma circulation.
Palabras clave en portugues
COVID-19SARS-CoV-2
Unidades de Terapia Intensiva
Pandemia
Rede Genômica Fiocruz
GENOMAHCOV
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