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Tipo
ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2023
Colecciones
- IOC - Artigos de Periódicos [12747]
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NATURAL PRODUCTS TARGETING INTO CANCER HALLMARKS: AN UPDATE ON CAFFEINE, THEOBROMINE, AND (Þ)-CATECHIN
Afiliación
Universidade Franciscana. Programa de Pós-Graduação em Saúde e Ciências da Vida. Santa Maria, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil.
Universidade Franciscana. Programa de Pós-Graduação em Saúde e Ciências da Vida. Santa Maria, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil.
Universidade Franciscana. Programa de Pós-Graduação em Saúde e Ciências da Vida. Santa Maria, RS, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica Experimental e Computacional de Fármacos. Rio de Janeiro, RJ, Brasil.
Resumen en ingles
Natural products have been studied to reveal new therapies against human dysfunctions since
they present several medicinal properties. Caffeine, theobromine and (þ)-catechin are remarkable
natural agents in the class of methylxanthines and flavonoids. These bioactive molecules have sev eral biological activities, for instance, antioxidant, anti-inflammatory, and antitumor capacity. In
this sense, studies focusing on these molecules have been performed to discover new treatments
against diseases, such as cancer. Cancer is a serious public health problem worldwide responsible
for more than 70% of all deaths globally. Industrialized products associated with a sedentary life style and a diet low in antioxidants are related to neoplasms development. Unfortunately, many
types of cancers are extremely aggressive and untreatable since, in many cases, they are resistant
to chemotherapy. Therefore, revealing new strategies to block cancer growth is one of the biggest
challenges to science. In this context, despite the known anticancer actions of caffeine, theobro mine and (þ)-catechin, it is still essential to elucidate the causal antitumor mechanism of these
molecules by analyzing the dysfunctional cancer pathways associated with the hallmarks of cancer.
Hence, this review aims to describe the anticancer activity of caffeine, theobromine, and (þ)-cat echin against the different hallmarks and enabling characteristics of cancer.
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