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GENOMIC EVIDENCE OF SARS-COV-2 REINFECTION INVOLVING E484K SPIKE MUTATION, BRAZIL
Nonaka, Carolina Kymie Vasques et al. | Date Issued: 2021
Author
Nonaka, Carolina Kymie Vasques
Franco, Marília Miranda
Gräf, Tiago
Barcia, Camila Araújo de Lorenzo
Mendonça, Renata Naves de Ávila
Sousa, Karoline Almeida Felix de
Neiva, Leila Machado Costa
Fosenca, Vagner
Mendes, Ana Verena Almeida
Aguiar, Renato Santana de
Giovanetti, Marta
Souza, Bruno Solano de Freitas
Affilliation
Instituto D'Or de Ensino e Pesquisa. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.
Hospital São Rafael. Departamento de Infectologia. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospital São Rafael. Departamento de Infectologia. Salvador, BA, Brasil.
Hospital São Rafael. Departamento de Infectologia. Salvador, BA, Brasil.
Hospital São Rafael. Departamento de Infectologia. Salvador, BA, Brasil.
São Rafael Hospital. Department of Infectology. Salvador, BA, Brazil.
Ministério da Saúde. Coordenação Geral dos Laboratórios de Saúde Pública. Brasília, DF, Brasil / University of KwaZulu-Natal. College of Health Sciences. Durban, South Africa / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
Hospital São Rafael. Departamento de Infectologia. Salvador, BA, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil / University Campus Bio-Medico of Rome. Unit of Medical Statistics and Molecular Epidemiology. Rome, Italy.
Instituto D'Or de Ensino e Pesquisa. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil.
Abstract
Uncertainty remains about how long the protective immune responses against severe acute respiratory syndrome coronavirus 2 persists, and suspected reinfection in recovered patients has been reported. We describe a case of reinfection from distinct virus lineages in Brazil harboring the E484K mutation, a variant associated with escape from neutralizing antibodies.
Keywords in Portuguese
Coronavirus
Síndrome Respiratória Aguda Grave
Mutação
Sars-CoV-2
 
Keywords
Coronavirus
Severe Acute Respiratory Syndrome
Mutation
SARS-Cov-2
 
Publisher
Centers for Disease Control and Prevention
Citation
NONAKA, Carolina Kymie Vasques et al. Genomic evidence of SARS-CoV-2 reinfection involving E484K spike mutation, Brazil. Emerging Infectious Diseases, v. 27, n. 5, May 2021.
DOI
10.3201/eid2705.210191
ISSN
1080-6040