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BIOLOGICAL ACTIVITIES OF THE ESSENTIAL OIL FROM THE LEAVES OF LANTANA MONTEVIDENSIS (SPRENG) BRIQ. IN MICE
Oliveira, Maria Rayane Correia de et al. | Data do documento: 2021
Autor(es)
Oliveira, Maria Rayane Correia de
Silva, Maria Gabriely de Lima
Alcântara, Isabel Sousa
Ribeiro Filho, Jaime
Tintino, Cícera Datiane de Morais Oliveira
Magalhães, Francisco Ernani Alves
Martins, Anita Oliveira Brito Pereira Bezerra
Pessoa, Renata Torres
Duarte, Antonia Eliene
Costa, José Galberto Martins da
Lima, Sidney Gonçalo de
Coutinho, Henrique Douglas Melo
Capasso, Raffaele
Menezes, Irwin Rose Alencar de
Afiliação
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Pernambuco. Laboratory of Pharmacotoxicological Prospecting of Bioactive Products. Department of Antibiotics. Recife, PE, Brazil.
State University of Ceará. Center of Education, Sciences and Technology of the Inhamuns Region. Laboratory of Bioprospecting of Natural Products and Biotechnology. Tauá, CE, Brazil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Center for Biological and Health Sciences. Department of Biological Sciences. Crato, CE, Brazil.
Regional University of Cariri. Laboratory of Prospecting of Natural Products, Department of Biological Chemistry. Crato, CE, Brazil.
Federal University of Piauí. Center for Natural Sciences. Laboratory of Organic Geochemistry. Teresina, PI, Brazil.
Regional University of Cariri. , Department of Biological Chemistry. Laboratory of Microbiology and Molecular Biology. Crato, CE, Brazil.
University of Naples Federico II. Department of Agricultural Sciences. Portici, Italy.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brazil.
Resumo em Inglês
This work aimed to analyze the chemical composition and evaluate the anti-inflammatory and antinociceptive properties of the essential oil obtained from the leaves of Lantana montevidensis (OEFLM) in mice. The chemical composition of the OEFLM was analyzed by GC–MS, and its effects on the central nervous system were determined by the open field and rotarod tests. The antinociceptive and anti-inflammatory screenings were conducted using the formalin test, as well as the acetic acid-induced abdominal contortion assay. The antinociceptive activity was assessed by the tail-flick and hot plate tests. The systemic anti-inflammatory activity was determined using models of paw edema induced by carrageenan, dextran, histamine, or arachidonic acid. The effects of the essential oil on vascular permeability and granuloma formation were also investigated. The chemical composition of the OEFLM revealed the presence of valencene (17.93%), bicyclogermacrene (16.35%), trans-caryophyllene (12.84%) and germacrene D (12.18%). The administration of OEFLM at the dose of 2000 mg/Kg caused no evident toxicity. While OEFLM (25, 50, 100, and 200 mg/kg) did not present significant anxiolytic-loke or sedative effects, it showed promising antinociceptive and anti-inflammatory activities. The results of this study indicate that the OEFLM has analgesic and anti-inflammatory activities in animal models by inhibiting acute and chronic inflammation.
Palavras-chave
Lantana
Inflamação
Ácido Araquidônico
Histamina
Camundongos
 
Palavras-chave em inglês
Essential oil ·
Lantana montevidensis ·
Anti-inflammatory activity ·
Antinociceptive activity
 
Editor
Springer
Referência
OLIVEIRA, Maria Rayane Correia de et al. Biological activities of the essential oil from the leaves of Lantana montevidensis (Spreng) Briq. in mice. Environment, Development and Sustainability, 2021.
ISSN
1387-585X
Notas
Ribeiro Filho, Jaime. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. “Documento protegido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.