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https://www.arca.fiocruz.br/handle/icict/46084
CHALLENGES AND THERAPEUTIC OPPORTUNITIES OF AUTOPHAGY IN CANCER THERAPY
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.
Resumo em Inglês
Autophagy is a physiological cellular process that is crucial for development and can occurs
in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual
role in cancer cells—while in some situations, it has a cytoprotective e ect that causes chemotherapy
resistance, in others, it has a cytotoxic e ect in which some compounds induce autophagy-mediated
cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer,
including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause
autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer
stem cells has also been discussed.
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