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ASSOCIATION OF VEGETABLE AND ANIMAL FLESH INTAKE WITH INFLAMMATION IN PREGNANT WOMEN FROM INDIA
Meat intake
Monocyte activation
Gut barrier
Inflammation
Pregnancy
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Resumen en ingles
In pregnant women, studies are lacking on the relationship of vegetable and animal flesh
(poultry, red meat and seafood) intake with inflammation, especially in low- and middle-income
countries. We conducted a cohort study of pregnant women receiving antenatal care at BJ Medical
College in Pune, India. The dietary intake of pregnant women was queried in the third trimester
using a validated food frequency questionnaire. Twelve inflammatory markers were measured in
plasma samples using immunoassays. Only 12% of the study population were vegetarians, although
animal flesh intake levels were lower compared to Western populations. In multivariable models,
higher intakes of total vegetables were associated with lower levels of the T-helper (Th) 17 cytokine
interleukin (IL)-17a (p = 0.03) and the monocyte/macrophage activation marker soluble CD163
(sCD163) (p = 0.02). Additionally, higher intakes of poultry were negatively associated with intestinal fatty-acid binding protein (I-FABP) levels (p = 0.01), a marker of intestinal barrier dysfunction and Th2
cytokine IL-13 (p = 0.03), and higher seafood was associated with lower IL-13 (p = 0.005). Our data
from pregnant women in India suggest that a higher quality diet emphasizing vegetables and with
some animal flesh is associated with lower inflammation. Future studies should confirm these
findings and test if modulating vegetables and animal flesh intake could impact specific aspects of
immunity and perinatal health.
Palabras clave en ingles
Vegetable intakeMeat intake
Monocyte activation
Gut barrier
Inflammation
Pregnancy
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