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https://www.arca.fiocruz.br/handle/icict/4590
ORAL TRANSMISSION OF CHAGAS DISEASE: IMPORTANCE OF TRYPANOSOMA CRUZI BIODEME IN THE INTRAGASTRIC EXPERIMENTAL INFECTION.
Oral transmission
Experimental intragastric infection; T.cruzi strains infectivity
Biodemes.
Trypanosoma cruzi/patogenicidade
Animais
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Modelos Animais de Doenças
Camundongos
Fatores de Tempo
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas
devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles,
results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes
was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain
(Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was
performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of
infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal
inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric
inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains
belonging to Biodeme III are most often found in sylvatic hosts.
Keywords in Portuguese
Trypanosoma cruziOral transmission
Experimental intragastric infection; T.cruzi strains infectivity
Biodemes.
DeCS
Doença de Chagas/transmissãoTrypanosoma cruzi/patogenicidade
Animais
Doença de Chagas/parasitologia
Doença de Chagas/patologia
Modelos Animais de Doenças
Camundongos
Fatores de Tempo
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