Por favor, use este identificador para citar o enlazar este ítem:
Tipo
ArtículoDerechos de autor
Acceso abierto
Colecciones
Metadatos
Mostrar el registro completo del ítem
GRANZYME B PRODUCED BY NATURAL KILLER CELLS ENHANCES INFLAMMATORY RESPONSE AND CONTRIBUTES TO THE IMMUNOPATHOLOGY OF CUTANEOUS LEISHMANIASIS
Leishmaniose cutânea
Atividade citotóxica
Granzyme B
Células NK
Cutaneous leishmaniasis
Cytotoxic activity
Granzyme B
NK cells
Autor
Afiliación
Resumen en ingles
Skin lesions from patients infected with Leishmania braziliensis has been associated with inflammation induced by cytotoxic CD8+ T cells. In addition, CD8+ T cell-mediated cytotoxicity has not been linked to parasite killing. Meanwhile, the cytotoxic role played by natural killer (NK) cells in cutaneous leishmaniasis (CL) remains poorly understood. Methods. In this study, we observed higher frequencies of NK cells in the peripheral blood of CL patients compared with healthy subjects, and that NK cells expressed more interferon-γ, tumor necrosis factor (TNF), granzyme B, and perforin than CD8+ T cells. Results. We also found that most of the cytotoxic activity in CL lesions was triggered by NK cells, and that the high levels of granzyme B produced in CL lesions was associated with larger lesion size. Furthermore, an in vitro blockade of granzyme B was observed to decrease TNF production. Concclusions. Our data, taken together, suggest an important role by NK cells in inducing inflammation in CL, thereby contributing to disease immunopathology.
Palabras clave en portugues
Células T CD8 +Leishmaniose cutânea
Atividade citotóxica
Granzyme B
Células NK
Palabras clave en ingles
CD8+ T cellsCutaneous leishmaniasis
Cytotoxic activity
Granzyme B
NK cells
Compartir