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YELLOW FEVER TRANSMISSION IN NON-HUMAN PRIMATES, BAHIA, NORTHEASTERN BRAZIL
Transmissão
Virus da febre amarela
Serviços de Vigilância Epidemiológica
Brasil
Transmission
Yellow fever virus
Epidemiologic Surveillance Services
Brazil
Autor(es)
Afiliação
Resumo em Inglês
Yellow fever virus (YFV) causes a clinical syndrome of acute hemorrhagic hepatitis. YFV
transmission involves non-human primates (NHP), mosquitoes and humans. By late 2016,
Brazil experienced the largest YFV outbreak of the last 100 years, with 2050 human confirmed
cases, with 681 cases ending in death and 764 confirmed epizootic cases in NHP.
Among affected areas, Bahia state in Northeastern was the only region with no autochthonous
human cases. By using next generation sequence approach, we investigated the
molecular epidemiology of YFV in NHP in Bahia and discuss what factors might have prevented
human cases. We investigated 47 YFV positive tissue samples from NHP cases to
generate 8 novel YFV genomes. ML phylogenetic tree reconstructions and automated subtyping
tools placed the newly generated genomes within the South American genotype I (SA
I). Our analysis revealed that the YFV genomes from Bahia formed two distinct well-supported phylogenetic clusters that emerged most likely of an introduction from Minas
Gerais and Espı´rito Santo states. Vegetation coverage analysis performed shows predominantly
low to medium vegetation coverage in Bahia state. Together, our findings support the
hypothesis of two independent YFV SA-I introductions. We also highlighted the effectiveness
of the actions taken by epidemiological surveillance team of the state to prevented
human cases.
Palavras-chave
Febre amarelaTransmissão
Virus da febre amarela
Serviços de Vigilância Epidemiológica
Brasil
Palavras-chave em inglês
Yellow FeverTransmission
Yellow fever virus
Epidemiologic Surveillance Services
Brazil
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