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https://www.arca.fiocruz.br/handle/icict/44535
GROSS MOTOR FUNCTION IN CHILDREN WITH CONGENITAL ZIKA SYNDROME
Autor(es)
Takahasi, Eliana Harumi Morioka
Alves, Maria Teresa Seabra Soares de Britto
Ribeiro, Marizélia Rodrigues Costa
Souza, Valéria Ferreira Pereira
Simões, Vanda Maria Ferreira
Borges, Marcella Costa Ribeiro
Amaral, Gláucio Andrade
Gomes, Lillian Nunes
Cunha, Antonio Ricardo Khouri
Sousa, Patricia da Silva
Silva, Antônio Augusto Moura da
Alves, Maria Teresa Seabra Soares de Britto
Ribeiro, Marizélia Rodrigues Costa
Souza, Valéria Ferreira Pereira
Simões, Vanda Maria Ferreira
Borges, Marcella Costa Ribeiro
Amaral, Gláucio Andrade
Gomes, Lillian Nunes
Cunha, Antonio Ricardo Khouri
Sousa, Patricia da Silva
Silva, Antônio Augusto Moura da
Afiliação
Sarah Network of Neurorehabilitation Hospitals. São Luís, MA, Brazil / Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
State Department of Health of the State of Maranhão. Reference Center on Neurodevelopment. Assistance and Rehabilitation of Children. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of São Paulo. Diagnostic Imaging Department. São Paulo, SP, Brazil.
Sarah Network of Neurorehabilitation Hospitals. São Luís, MA, Brazil
University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology Human. Department of Immunology. São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Faculty of Medicine. Department of Pathology and Legal Medicine. Salvador, BA, Brazil.
State Department of Health of the State of Maranhão. Reference Center on Neurodevelopment. Assistance and Rehabilitation of Children. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
State Department of Health of the State of Maranhão. Reference Center on Neurodevelopment. Assistance and Rehabilitation of Children. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Federal University of São Paulo. Diagnostic Imaging Department. São Paulo, SP, Brazil.
Sarah Network of Neurorehabilitation Hospitals. São Luís, MA, Brazil
University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology Human. Department of Immunology. São Paulo, SP, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Faculty of Medicine. Department of Pathology and Legal Medicine. Salvador, BA, Brazil.
State Department of Health of the State of Maranhão. Reference Center on Neurodevelopment. Assistance and Rehabilitation of Children. São Luís, MA, Brazil.
Federal University of Maranhão. Public Health Department. São Luís, MA, Brazil.
Resumo em Inglês
Little information on gross motor function of congenital Zika syndrome
(CZS) children is available.
Objectives To evaluate gross motor function in CZS children aged up to 3 years, and
its associated factors and changes in a minimum interval of 6 months.
Methods One hundred children with CZS and cerebral palsy (36 with confirmed and
64 with presumed CZS) were evaluated with the Gross Motor Function Classification
System (GMFCS) and Gross Motor Function Measure (GMFM-88/GMFM-66). Forty-six
were reevaluated. Wilcoxon tests,Wilcoxon tests for paired samples, percentile scores,
and score changes were performed.
Results Clinical and socioeconomic characteristics (except maternal age), GMFM
scores and GMFCS classification of confirmed and probable cases, which were analyzed
together, were similar. The mean age was 25.6 months ( 5.5); the median GMFM-88
score was 8.0 (5.4–10.8); and the median GMFM-66 score was 20.5 (14.8–23.1); 89%
were classified as GMFCS level V. Low economic class, microcephaly at birth, epilepsy,
and brain parenchymal volume loss were associated with low GMFM-66 scores. The
median GMFM-66 percentile score was 40 (20–55). On the second assessment, the
GMFM-66 scores in two GMFCS level I children and one GMFCS level IV child improved
significantly. In one GMFCS level III child, one GMFCS level IV child, and the group of
GMFCS level V children, no significant changes were observed.
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