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PSEUDOMONAS AERUGINOSA: STUDY OF ANTIBIOTIC RESISTANCE AND MOLECULAR TYPING IN HOSPITAL INFECTION CASES IN A NEONATAL INTENSIVE CARE UNIT FROM RIO DE JANEIRO CITY, BRAZIL
Unidade de terapia intensiva neonatal
Sépsis
Infecção hospitalar
Rio de Janeiro
Brasil
Neonatal intensive care unit
Hospital infection
Sepsis
Rio de Janeiro
Brazil
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Hospital Maternidade Alexander Fleming II. Sistema Único de Saúde. Rio de Janeiro, RJ, Brasil.
Hospital Maternidade Alexander Fleming II. Sistema Único de Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Hospital Maternidade Alexander Fleming II. Sistema Único de Saúde. Rio de Janeiro, RJ, Brasil.
Hospital Maternidade Alexander Fleming II. Sistema Único de Saúde. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Bacteriologia. Laboratório de Enterobactérias. Rio de Janeiro, RJ, Brasil.
Abstract
This study had the objective of to analyze the demographic and bacteriologic data of 32 hospitalized newborns
in an neonatal intensive care unit of a public maternity hospital in Rio de Janeiro city, Brazil, seized by Pseudomonas aeruginosa sepsis during a period ranged from July 1997 to July 1999, and to determine the antimicrobial
resistance percentage, serotypes and pulsed field gel electrophoresis (PFGE) patterns of 32 strains isolated during
this period. The study group presented mean age of 12.5 days, with higher prevalence of hospital infection in males
(59.4%) and vaginal delivery (81.2%), than females (40.6%) and cesarean delivery (18.8%), respectively. In this
group, 20 (62.5%) patients received antimicrobials before positive blood cultures presentation. A total of 87.5% of
the patients were premature, 62.5% presented very low birth weight and 40.6% had asphyxia. We detected high
antimicrobial resistance percentage to β-lactams, chloramphenicol, trimethoprim/sulfamethoxazole and tetracycline among the isolated strains. All isolated strains were classified as multi-drug resistant. Most strains presented
serotype O11 while PFGE analysis revealed seven distinct clones with isolation predominance of a single clone
(75%) isolated from July 1997 to June 1998.
Keywords in Portuguese
Pseudomonas aeruginosaUnidade de terapia intensiva neonatal
Sépsis
Infecção hospitalar
Rio de Janeiro
Brasil
Keywords
Pseudomonas aeruginosaNeonatal intensive care unit
Hospital infection
Sepsis
Rio de Janeiro
Brazil
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