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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12747]
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PHENOTYPES OF LUNG MONONUCLEAR PHAGOCYTES IN HIV SERONEGATIVE TUBERCULOSIS PATIENTS: EVIDENCE FOR NEW RECRUITMENT AND CELL ACTIVATION
Alveolar macrophages
Activation
Monoclonal antibodies
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Hospital Evandro Chagas. Laboratório de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Humana. Rio de Janeiro, RJ, Brasil.
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Laboratório Multidisciplinar de Pesquisa e Serviço de Pneumologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Humana. Rio de Janeiro, RJ, Brasil.
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.
Cornell University Medical College. Division of International Medicine and Infectious Diseases. New York, NY, USA.
Resumo em Inglês
Mycobacterium tuberculosis preferentially resides in mononuclear phagocytes. The mechanisms by
which mononuclear phagocytes keep M. tuberculosis in check or by which the microbe evades control to
cause disease remain poorly understood. As an initial effort to delineate these mechanisms, we examined by immunostaining the phenotype of mononuclear phagocytes obtained from lungs of patients with
active tuberculosis. From August 1994 to March 1995, consecutive patients who had an abnormal chest
X-ray, no demostrable acid-fast bacilli in sputum specimens and required a diagnostic bronchoalveolar
lavage (BAL) were enrolled. Of the 39 patients enrolled, 21 had microbiologically diagnosed tuberculosis. Thirteen of the 21 tuberculosis patients were either HIV seronegative (n = 12) or had no risk factor
for HIV and constituted the tuberculosis group. For comparison, M. tuberculosis negative patients who
had BAL samples taken during this time (n = 9) or normal healthy volunteers (n = 3) served as control
group. Compared to the control group, the tuberculosis group had significantly higher proportion of
cells expressing markers of young monocytes (UCHM1) and RFD7, a marker for phagocytic cells, and
increased expression of HLA-DR, a marker of cell activation. In addition, tuberculosis group had significantly higher proportion of cells expressing dendritic cell marker (RFD1) and epithelioid cell marker
(RFD9). These data suggest that despite recruitment of monocytes probably from the peripheral blood
and local cell activation, host defense of the resident lung cells is insufficient to control M. tuberculosis.
Palavras-chave em inglês
Pulmonary tuberculosisAlveolar macrophages
Activation
Monoclonal antibodies
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