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SCREENING OF THE ANTIMALARIAL ACTIVITY OF PLANTS OF THE CUCURBITACEAE FAMILY
Cucurbitaceae
Momordica charantia
Plasmodium berghei
Rastreio de drogas
Extratos vegetais
Antimaláricos
Terapia medicamentosa
Drug therapy
Natural products
Plant extracts
Drug screening
Plasmodium berghei
Curcubita maxima
Momordica charantia
Cucurbitaceae
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Rio de Janeiro, RJ, Brasil.
Abstract
Crude ethanolic extracts (CEEs) from two species of Cucurbitaceae, Cucurbita maxima and Momordica charantia (commonly called "abóbora moranga" and melão de São Caetano", respectively) were assayed for antimalarial activity by the 4-d suppressive test. The CEE of dry C. maxima seeds showed strong antimalarial activity following oral administration (259 and 500 mg/kg), reducing by 50% the levels of parasistemia in Plasmodium berghey-infected mice. Treatment of normal animals with 500 mg/Kg of the extract three days before intravenous injection of P. berghei caused a significant 30% reduction in parasitemic levels. No effect was observed when the animals were treated with the CEE only on the day of inoculation. Oral administration of the CEE of dry M. charantia leaves adminstered orally was ineffective up to 500 mg/Kg in lowering the parasitemic levels of malarious mice.
Keywords in Portuguese
Plasmodium bergheiCucurbitaceae
Momordica charantia
Plasmodium berghei
Rastreio de drogas
Extratos vegetais
Antimaláricos
Terapia medicamentosa
Keywords
AntimalarialsDrug therapy
Natural products
Plant extracts
Drug screening
Plasmodium berghei
Curcubita maxima
Momordica charantia
Cucurbitaceae
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