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LIPID DROPLETS ACCUMULATE IN THE HYPOTHALAMUS OF MICE AND HUMANS WITH AND WITHOUT METABOLIC DISEASES
Gotícula lipídica
Hipotálamo
Resistência à insulina
Tipo 2 Diabestes Mellitus
Lipid droplet
Hypothalamus
Insulin resistance
PLIN2
Type 2 Diabestes Mellitus
Autor
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil / Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the Netherlands
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Department of Nutrition and Movement Sciences. Maastricht University Medical Centre+ and NUTRIM School for Nutrition and Translational Research in Metabolism. Maastricht, the Netherlands
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands / Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands.
Laboratory of Endocrinology and Department of Endocrinology and Metabolism, Amsterdam Neuroscience, Amsterdam University Medical Centers (UMC), University of Amsterdam, Amsterdam, the Netherlands.
Resumen en ingles
In peripheral tissues, the lipid droplet (LD) organelle links lipid metabolism,
inflammation and insulin resistance. Little is known about the brain LDs. Objectives: We
hypothesised that hypothalamic LDs would be altered in metabolic diseases. Methods: We
used immunofluorescence for the specific LD protein, PLIN2, as the marker to visualize and
quantify LDs.
Palabras clave en portugues
CérebroGotícula lipídica
Hipotálamo
Resistência à insulina
Tipo 2 Diabestes Mellitus
Palabras clave en ingles
BrainLipid droplet
Hypothalamus
Insulin resistance
PLIN2
Type 2 Diabestes Mellitus
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