Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/4203
Tipo
ArtículoDerechos de autor
Acceso abierto
Colecciones
Metadatos
Mostrar el registro completo del ítem
MENINGOENCEPHALITIS CAUSED BY A ZYGOMYCETE FUNGUS (BASIDIOBOLUS) ASSOCIATED WITH SEPTIC SHOCK IN AN IMMUNOCOMPETENT PATIENT: 1-YEAR FOLLOW-UP AFTER TREATMENT
Autor
Afiliación
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Universidade de São Paulo . Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Social , Ribeirão Preto, SP, Brasil
Divisão de Neurocirurgia, Departamento de Cirurgia e Anatomia, Hospital das Clínicas.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia.Ribeirão Preto, SP, Brasil
Fundação Oswaldo Cruz . Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brasil
Universidade de São Paulo . Faculdade de Medicina de Ribeirão Preto. Departamento de Medicina Social , Ribeirão Preto, SP, Brasil
Divisão de Neurocirurgia, Departamento de Cirurgia e Anatomia, Hospital das Clínicas.Ribeirão Preto, SP, Brasil
Divisão de Terapia Intensiva, Departamento de Cirurgia e Anatomia
Resumen en ingles
Zygomycosis is an infection caused by opportunistic fungi of the Zygomycetes class, specifically those from the Mucorales and Entomophthorales orders. It is an uncommon disease, mainly restricted to immunocompromised patients. We report a case of a 73-year-old male patient with a history of fever (39°C) lasting for 1 day, accompanied by shivering, trembling, and intense asthenia. The patient was admitted to the intensive care unit with complex partial seizures, and submitted to orotracheal intubation and mechanical ventilation under sedation with midazolam. The electroencephalogram showed evidence of non-convulsive status epilepticus. There is no fast specific laboratory test that permits confirmation of invasive fungal disease. Unless the physician suspects this condition, the disease may progress rapidly while the patient is treated with broad-spectrum antibiotics. Differential diagnosis between fungal and bacterial infection is often difficult. The clinical presentation is sometimes atypical, and etiological investigation is not always successful. In the present case, the histopathological examination of the biopsy obtained from the right temporal lobe indicated the presence of irregular, round, thick-walled fungi forming papillae and elongated structures of irregular diameter, with no septa, indicative of zygomycete (Basidiobolus). Treatment with liposomal amphotericin B and fluconazole was initiated after diagnosis of meningoencephalitis by zygomycete, with a successful outcome.
Compartir