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NOOTKATONE INHIBITS ACUTE AND CHRONIC INFLAMMATORY RESPONSES IN MICE
Autor
Dantas, Lindaiane Bezerra Rodrigues
Silva, Ana Letícia Moreira
Silva Júnior, Cícero Pedro da
Alcântara, Isabel Sousa
Oliveira, Maria Rayane Correia de
Martins, Anita Oliveira Brito Pereira Bezerra
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
Passos, Fabíolla Rocha Santos
Quintans Junior, Lucindo José
Menezes, Irwin Rose Alencar de
Pezzani, Raffaele
Vitalini, Sara
Silva, Ana Letícia Moreira
Silva Júnior, Cícero Pedro da
Alcântara, Isabel Sousa
Oliveira, Maria Rayane Correia de
Martins, Anita Oliveira Brito Pereira Bezerra
Ribeiro Filho, Jaime
Coutinho, Henrique Douglas Melo
Passos, Fabíolla Rocha Santos
Quintans Junior, Lucindo José
Menezes, Irwin Rose Alencar de
Pezzani, Raffaele
Vitalini, Sara
Afiliación
Centro Universitário Dr. Leão Sampaio-UNILEÃO. Departamento de Saúde. Juazeiro do Norte, CE, Brasil.
Centro Universitário Dr. Leão Sampaio-UNILEÃO. Departamento de Saúde. Juazeiro do Norte, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Regional University of Cariri. Microbiology and Biology Molecular Laboratory. Department of Chemical Biology. Crato, CE, Brasil.
Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil.
Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
University of Padova. O.U. Endocrinology, Department of Medicine. Padova, Italy / Associazione Italiana per la Ricerca Oncologica di Base. Padova, Italy.
Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy.
Centro Universitário Dr. Leão Sampaio-UNILEÃO. Departamento de Saúde. Juazeiro do Norte, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Regional University of Cariri. Microbiology and Biology Molecular Laboratory. Department of Chemical Biology. Crato, CE, Brasil.
Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil.
Federal University of Sergipe. Graduate Program in Health Sciences. Aracaju, SE, Brasil.
Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry. Crato, CE, Brasil.
University of Padova. O.U. Endocrinology, Department of Medicine. Padova, Italy / Associazione Italiana per la Ricerca Oncologica di Base. Padova, Italy.
Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy.
Resumen en ingles
Nootkatone (NTK) is a sesquiterpenoid found in essential oils of many species of Citrus (Rutaceae). Considering previous reports demonstrating that NTK inhibited inflammatory signaling pathways, this study aimed to investigate the effects of this compound in mice models of acute and chronic inflammation. Murine models of paw edema induced by carrageenan, dextran, histamine, and arachidonic acid, as well as carrageenan-induced peritonitis and pleurisy, were used to evaluate the effects of NTK on acute inflammation. A murine model of granuloma induced by cotton pellets was used to access the impact of NTK treatment on chronic inflammation. In the acute inflammation models, NTK demonstrated antiedematogenic effects and inhibited leukocyte recruitment, which was associated with decreased vascular permeability, inhibition of myeloperoxidase (MPO), interleukin (IL)1-β, and tumor necrosis factor (TNF)-α production. In silico analysis suggest that NTZ anti-inflammatory effects may also occur due to inhibition of cyclooxygenase (COX)-2 activity and antagonism of the histamine receptor type 1 (H1). These mechanisms might have contributed to the reduction of granuloma weight and protein concentration in the homogenates, observed in the chronic inflammation model. In conclusion, NTK exerted anti-inflammatory effects that are associated with inhibition of IL1-β and TNF-α production, possibly due to inhibition of COX-2 activity and antagonism of the H1 receptor. However, further studies are required to characterize the effects of this compound on chronic inflammation.
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