Trans-Atlantic Spill Over: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France.
Institut Pasteur, INSERN U1201. Department of Parasites and Insect Vectors.Laboratory of Molecular Parasitology and Signaling. Paris, France / Institut Pasteur-Bioinformatics and Biostatistics Hub-C3BI, USR 3756 IP CNRS, 75015 Paris, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.
University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK.
University of Glasgow. Institute of Biodiversity, Animal Health & Comparative Medicine. Glasgow, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmaniose. Rio de Janeiro, RJ, Brasil.

Resumen en ingles

Pathogen fitness landscapes change when transmission cycles establish in non-native environments or spill over into new vectors and hosts. The introduction of Leishmania infantum in the Americas into the Neotropics during European colonization represents a unique case study to investigate the mechanisms of ecological adaptation of this important parasite. Defining the evolutionary trajectories that drive L. infantum fitness in this new environment are of great public health importance as they will allow unique insight into pathways of host/pathogen co-evolution and their consequences for region-specific changes in disease manifestation. This review summarizes current knowledge on L. infantum genetic and phenotypic diversity in the Americas and its possible role in the unique epidemiology of visceral leishmaniasis (VL) in the New World. We highlight the importance of appreciating adaptive molecular mechanisms in L. infantum to understand the parasites' successful establishment on the continent.

Palabras clave en portugues

Leishmania
Leishmaniose visceral
Américas
Instabilidade do genoma
Adaptação

Palabras clave en ingles

Leishmania
Visceral leishmaniasis;
Americas
Genome instability
Adaptation

Editor

MDPI

Referencia

BOITÉ, Mariana C. et al. Trans-Atlantic Spillover: Deconstructing the Ecological Adaptation of Leishmania infantum in the Americas. Genes, v. 11, n. 4, 11p, 2020.

DOI

10.3390/genes11010004

ISSN

2073-4425

Por favor, use este identificador para citar o enlazar este ítem: https://www.arca.fiocruz.br/handle/icict/41021

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