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2020-01-01
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TOLL-LIKE RECEPTOR-2-MEDIATED C-C CHEMOKINE RECEPTOR 3 AND EOTAXIN-DRIVEN EOSINOPHIL INFLUX INDUCED BY MYCOBACTERIUM BOVIS BCG PLEURISY
D'Avila, Heloisa et al. | Date Issued: 2007
Author
D'Avila, Heloisa
Almeida, Patrícia E.
Roque, Natália R.
Faria Neto, Hugo Caire C.
Bozza, Patrícia T.
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Fisiologia e Farmacodinâmica. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
Abstract
An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation.
Keywords in Portuguese
Influxo de Eosinófilos
Eotaxina
Mycobacterium bovis BCG Pleurisia
Receptor C-C Mediado por Quimiocina
 
Keywords
Toll-Like Receptor-2
Mediated C-C Chemokine
Mycobacterium bovis BCG Pleurisia
Eosinophil Influx
 
Publisher
American Society for Microbiology
Citation
D`ÁVILA, Heloisa et al. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infection and Immunity, v. 75, n. 3, p. 1507-1522, Mar. 2007.
DOI
10.1128/IAI.01326-06
ISSN
0019-9567
Notes
Acesso aberto em 20/04/2020 - https://iai.asm.org/content/iai/75/3/1507.full.pdf