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ArtigoDireito Autoral
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- BA - IGM - Artigos de Periódicos [3689]
- IOC - Artigos de Periódicos [12791]
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NEONATAL SURVEILLANCE FOR CONGENITAL ZIKA INFECTION DURING THE 2016 MICROCEPHALY OUTBREAK IN SALVADOR, BRAZIL: ZIKA VIRUS DETECTION IN ASYMPTOMATIC NEWBORNS
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Resumo em Inglês
To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak. Methods: A prospective study enrolled microcephalic and normocephalic newborns
with suspected CZI between January and December 2016. Serology (immunoglobulins
IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction
(RT-qPCR)
for the Zika virus were performed. Demographic and clinical characteristics
of newborns with and without microcephaly were compared.
Results: Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic.
The majority of these cases were born between January and May 2016. IgM and
IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic
newborn blood samples, respectively. Six (24%) microcephalic newborns tested
positive for Zika virus by RT-qPCR
in urine or placenta samples. Thirteen (11.8%)
normocephalic newborns also tested positive for Zika virus by PCR in urine,
plasma, or placenta samples, while IgM antibodies against Zika were detected in 4
(4.2%) others.
Conclusions: Identification of 17 normocephalic CZI cases, confirmed by IgM serology
or RT-qPCR
for Zika virus, provides evidence that CZI can present asymptomatically at
birth. This finding highlights the need for prenatal and neonatal screening for Zika virus
in endemic regions.
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