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NEONATAL SURVEILLANCE FOR CONGENITAL ZIKA INFECTION DURING THE 2016 MICROCEPHALY OUTBREAK IN SALVADOR, BRAZIL: ZIKA VIRUS DETECTION IN ASYMPTOMATIC NEWBORNS
Author
Oliveira, João Vitor
Carvalho, Tereza Cristina Xavier
Giovanetti, Marta
Jesus, Jaqueline Goes de
Santos, Cleiton Silva
Pessoa, Lorena de Brito
Magalhães Filho, Cláudio F. Q.
Lima, Jéssica Graziele Souza
Carvalho, Daniel A. X.
Figueiredo, Eduardo Manoel
Biron, Ana Carolina
Santos, Daiana Carlos dos
Viana, Paloma
Duarte, Alan Oliveira
Pessoa, Rosana
Souza, Gloryane Bessa
Calcagno, Juan I
Lima, Fernanda Washington de Mendonça
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cerqueira de
Carvalho, Tereza Cristina Xavier
Giovanetti, Marta
Jesus, Jaqueline Goes de
Santos, Cleiton Silva
Pessoa, Lorena de Brito
Magalhães Filho, Cláudio F. Q.
Lima, Jéssica Graziele Souza
Carvalho, Daniel A. X.
Figueiredo, Eduardo Manoel
Biron, Ana Carolina
Santos, Daiana Carlos dos
Viana, Paloma
Duarte, Alan Oliveira
Pessoa, Rosana
Souza, Gloryane Bessa
Calcagno, Juan I
Lima, Fernanda Washington de Mendonça
Alcantara, Luiz Carlos Junior
Siqueira, Isadora Cerqueira de
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Hospítal José Maria de Magalhães Netto Maternity. Salvador, BA, Brasil.
Federal University of Bahia. Faculty of Pharmacy. Immunology of Infectious Diseases Laboratory. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Oswaldo Cruz Institute. Flavivirus Laboratory. Rio de Janeiro, RJ, Brazil / Federal University of Minas Gerais. Cell and Molecular Genetics Laboratory. Belo Horizonte, MG, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Abstract
To identify newborns with congenital Zika infection (CZI) at a maternity hospital in Salvador, Brazil, during the 2016 microcephaly outbreak. Methods: A prospective study enrolled microcephalic and normocephalic newborns
with suspected CZI between January and December 2016. Serology (immunoglobulins
IgM and IgG) and quantitative reverse transcriptase polymerase chain reaction
(RT-qPCR)
for the Zika virus were performed. Demographic and clinical characteristics
of newborns with and without microcephaly were compared.
Results: Of the 151 newborns enrolled, 32 (21.2%) were classified as microcephalic.
The majority of these cases were born between January and May 2016. IgM and
IgG Zika virus antibodies were detected in 5 (23.8%) and 17 (80.9%) microcephalic
newborn blood samples, respectively. Six (24%) microcephalic newborns tested
positive for Zika virus by RT-qPCR
in urine or placenta samples. Thirteen (11.8%)
normocephalic newborns also tested positive for Zika virus by PCR in urine,
plasma, or placenta samples, while IgM antibodies against Zika were detected in 4
(4.2%) others.
Conclusions: Identification of 17 normocephalic CZI cases, confirmed by IgM serology
or RT-qPCR
for Zika virus, provides evidence that CZI can present asymptomatically at
birth. This finding highlights the need for prenatal and neonatal screening for Zika virus
in endemic regions.
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