Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/37454
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Data de embargo
2020-11-28
Coleções
- INI - Artigos de Periódicos [3488]
Metadata
Mostrar registro completo
ASSOCIATION BETWEEN GC GENOTYPE AND SUSCEPTIBILITY TO TB IS DEPENDENT ON VITAMIN D STATUS
Autor(es)
Martineau, Adrian R.
Leandro, Ana Cristina C. S.
Anderson, Suzanne T.
Newton, Sandra M.
Wilkinson, Katalin A.
Nicol, Mark P.
Pienaar, Sandra M.
Skolimowska, Keira H.
Rocha, Marcia A.
Rolla, Valeria C.
Levin, Michael
Davidson, Robert N.
Bremner, Stephen A.
Griffiths, Christopher J.
Eley, Brian S.
Bonecini-Almeida, M. Glória
Wilkinson, Robert J.
Leandro, Ana Cristina C. S.
Anderson, Suzanne T.
Newton, Sandra M.
Wilkinson, Katalin A.
Nicol, Mark P.
Pienaar, Sandra M.
Skolimowska, Keira H.
Rocha, Marcia A.
Rolla, Valeria C.
Levin, Michael
Davidson, Robert N.
Bremner, Stephen A.
Griffiths, Christopher J.
Eley, Brian S.
Bonecini-Almeida, M. Glória
Wilkinson, Robert J.
Afiliação
Imperial College London. Wellcome Trust Centre for Research in Clinical Tropical Medicine. Division of Medicine. London, UK / Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK / National Institute of Medical Research. Division of Mycobacterial Research. London, UK.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa / University of Cape Town. Faculty of Health Sciences. Division of Medical Microbiology. Cape Town, South Africa / National Health Laboratory Services. Cape Town, South Africa.
University of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa / Red Cross Children’s Hospital. Cape Town, South Africa.
University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório Clínico em Tuberculose e Micobacterias. Rio de Janeiro, RJ, Brasil.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
North West London Hospitals NHS Trust. Northwick Park Hospital. Tuberculosis Clinic. London, UK.
Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK
Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK
University of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Imperial College London. Wellcome Trust Centre for Research in Clinical Tropical Medicine. Division of Medicine. London, UK / National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa / University of Cape Town. Faculty of Health Sciences. Division of Medical Microbiology. Cape Town, South Africa / National Health Laboratory Services. Cape Town, South Africa.
University of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa / Red Cross Children’s Hospital. Cape Town, South Africa.
University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório Clínico em Tuberculose e Micobacterias. Rio de Janeiro, RJ, Brasil.
Imperial College London. Division of Medicine. Academic Department of Paediatrics. London, UK.
North West London Hospitals NHS Trust. Northwick Park Hospital. Tuberculosis Clinic. London, UK.
Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK
Queen Mary’s. School of Medicine and Dentistry, Barts and The London. Centre for Health Sciences. London, UK
University of Cape Town. School of Child and Adolescent Health. Paediatric Infectious Diseases Unit. Cape Town, South Africa.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Imunologia e Imunogenética. Rio de Janeiro, RJ, Brasil.
Imperial College London. Wellcome Trust Centre for Research in Clinical Tropical Medicine. Division of Medicine. London, UK / National Institute of Medical Research. Division of Mycobacterial Research. London, UK / University of Cape Town. Faculty of Health Sciences. Institute of Infectious Diseases and Molecular Medicine. Cape Town, South Africa.
Resumo em Inglês
Gc variants of vitamin D binding protein differ in their affinity for vitamin D metabolites that modulate antimycobacterial immunity. We conducted studies to determine whether Gc genotype associates with susceptibility to tuberculosis. 123 adult tuberculosis patients and 140 controls of Gujarati Asian ethnic origin in the United Kingdom, 130 adult tuberculosis patients and 78 controls in Brazil, and 281 children with
tuberculosis and 182 controls in South Africa were recruited to case-control studies. Gc genotypes were determined and their frequency was compared between cases vs. controls. Serum 25-hydroxyvitamin D (25[OH]D) concentrations were obtained retrospectively for 139 Gujarati Asians, and case-control analysis was stratified by vitamin D status. Interferon-γ release assays were also performed on 36 Gujarati tuberculosis contacts. The Gc2/2 genotype was strongly associated with susceptibility to active tuberculosis in Gujarati Asians, compared with Gc1/1 genotype (OR 2.81, 95% CI 1.19 to 6.66, P=0.009). This association was preserved if serum 25(OH)D was <20 nmol/l (P=0.01), but not if serum 25(OH)D was ≥20 nmol/l (P=0.36). Carriage of the Gc2 allele associated with increased PPD-stimulated Interferon-γ release in Gujarati Asian tuberculosis contacts (P = 0.02). No association between Gc genotype and susceptibility to tuberculosis was observed in other ethnic groups studied.
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