Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort

Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / State University of Feira de Santana. Department of Health. Feira de Santana, BA, Brazil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Universidade Federal da Bahia, Instituto de Matemática. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil.
Federal University Fluminense. Department of Epidemiology and Biostatistics. Rio de Janeiro, RJ, Brazil.
London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.
London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.
London School of Hygiene & Tropical Medicine. Department of Non-communicable Disease Epidemiology. London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimentos para Saúde. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Fiocruz Brasília. Escola de Governo. Brasília, DF, Brasil / Universidade de Brasília. Centro de Medicina Tropical. Brasília, DF, Brasil.

Resumo em Inglês

Although leprosy is largely curable with multidrug therapy, incomplete treatment limits therapeutic effectiveness and is an important obstacle to disease control. To inform efforts to improve treatment completion rates, we aimed to identify the geographic and socioeconomic factors associated with leprosy treatment default in Brazil. Methodology/Principal findings Using individual participant data collected in the Brazilian national registries for social programs and notifiable diseases and linked as part of the 100 Million Brazilian Cohort, we evaluated the odds of treatment default among 20,063 leprosy cases diagnosed and followed up between 2007 and 2014. We investigated geographic and socioeconomic risk factors using a multivariate hierarchical analysis and carried out additional stratified analyses by leprosy subtype and geographic region. Over the duration of follow-up, 1,011 (5.0%) leprosy cases were observed to default from treatment. Treatment default was markedly increased among leprosy cases residing in the North (OR = 1.57; 95%CI 1.25–1.97) and Northeast (OR = 1.44; 95%CI 1.17–1.78) regions of Brazil.

Palavras-chave

Fatores socioeconomicos
Hanseniase
Tratamento
Análise de Coortes

Palavras-chave em inglês

Socioeconomic Factors
Leprosy
Treatment
Cohort Studies

Editor

Public Library of Science

Referência

ANDRADE, Kaio Vinicius Freitas de et al. Geographic and socioeconomic factors associated with leprosy treatment default: an analysis from the 100 Million Brazilian Cohort. Plos Neglected Tropical Diseases, p. 1-18, Sept. 2019.

DOI

10.1371/journal.pntd.0007714

ISSN

1935-2727

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/36841

Tipo de documento

Direito Autoral

Acesso aberto

Objetivos de Desenvolvimento Sustentável

Coleções

Compartilhar

Estatísticas

Metadata

Autor(es)

Afiliação