Autor
Afiliación
Resumen en ingles
Background: One of the most robust genetic associations for cardiovascular disease (CVD) is the Chromosome 9p21 region. However, the interaction of this locus with environmental factors has not been extensively explored. We investigated the association of 9p21 with myocardial infarction (MI) in individuals of different ethnicities, and tested for an interaction with environmental factors. Methods and Findings: We genotyped four 9p21 SNPs in 8,114 individuals from the global INTERHEART study. All four variants were associated with MI, with odds ratios (ORs) of 1.18 to 1.20 (1.8561028#p#5.2161027). A significant interaction (p = 4.061024 ) was observed between rs2383206 and a factor-analysis-derived ‘‘prudent’’ diet pattern score, for which a major component was raw vegetables. An effect of 9p21 on MI was observed in the group with a low prudent diet score (OR = 1.32, p = 6.8261027 ), but the effect was diminished in a step-wise fashion in the medium (OR = 1.17, p = 4.961023 ) and high prudent diet scoring groups (OR = 1.02, p = 0.68) (p = 0.014 for difference). We also analyzed data from 19,129 individuals (including 1,014 incident cases of CVD) from the prospective FINRISK study, which used a closely related dietary variable. In this analysis, the 9p21 risk allele demonstrated a larger effect on CVD risk in the groups with diets low or average for fresh vegetables, fruits, and berries (hazard ratio [HR] = 1.22, p = 3.061024, and HR = 1.35, p = 4.161023, respectively) compared to the group with high consumption of these foods (HR = 0.96, p = 0.73) (p = 0.0011 for difference). The combination of the least prudent diet and two copies of the risk allele was associated with a 2-fold increase in risk for MI (OR = 1.98, p = 2.1161029 ) in the INTERHEART study and a 1.66-fold increase in risk for CVD in the FINRISK study (HR = 1.66, p = 0.0026). Conclusions: The risk of MI and CVD conferred by Chromosome 9p21 SNPs appears to be modified by a prudent diet high in raw vegetables and fruits.
Editor
Public Library of Science
Referencia
DO, Ron et al. The effect of chromosome 9p21 variants on cardiovascular disease may be modified by dietary intake: evidence from a case/control and a prospective study. Plos Medicine, v. 8, n. 10, p. 1-10, 2011.
DOI
10.1371/journal.pmed.1001106
ISSN
1549-1277
Notas
Sérgio Salles Xavier. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
INTERHEART national coordinators* and investigators
Argentina: R Diaz*, E Paolasso*, M Ciruzzi*, Instituto Cardiovascular de Rosario R Nordaby, CH Sosa, HL Luciardi, EM Marzetti, JA Piasentin, M Muchastegui, C Cuneo, G Zapata, JO Bono, EM Marxetti, A Caccavo, RAA Guerrero, R Nordaby, C Dizeo; Australia and New Zealand: D Hunt*, J Varigos*, University of Melbourne, Royal Melbourne Hospital M Sallaberger, G Aroney, P Hicks, D Campbell, J Amerena, W Walsh, G Nelson, D Careless, J Durech, K Gunawardane, A Thomson, D Owensby, A Buncle, B Watson, H Ikram, M Audeau, M Hills, D Rosen, J Rankin, A Tunesi, J Sampson, K Roberts, A Hamer, L Roberts, B Singh, C Singh, R Hendriks, G Tulloch, A Hill, D Rees, C Hall; Bahrain: MA Halim*, Al Khalifa, Cardiac Centre MI Amin; Bangladesh: S Haque*, Sheik Mujih, Medical University/Institute of Post Grad Medicine GM Faruque, M Hossain; Benin Republic: H Agboton*, General Teaching Hospital/Medical School; Botswana: C Onen*, Center for Chronic Diseases, Gaborone Private Hospital, Gaborone; Brazil: A Avezum*, L Piegas*, Instituto Dante Pazzanese de Cardiologia, Sao Paulo G Reis, JP Esteves, LC Bodanese, AR Junior, JAM Neto, RF Ramos, ES Silva, A Labrunie, ACC Carvalho, IP Filho, DCD Albuquerque, JAM Abrantes, OCE Gebara, PE Leaes, SS Xavier, RL Marino, O Dutra; Cameroon: W Muna*, K N Blackett*, CHU, Yaoundé; Canada: K Teo*, S Yusuf*, Hamilton General Hospital, Hamilton S Ounpuu, YK Chan, C Joyner, AD Kitching, A Morris, A Panju, H Lee, I Bata, B May, JG Hiscock, PV Greenwood, W Tymchak, M Natarajan; Chile: F Lanas*, Facultad de Medicina, Universidad de la Frontera, Temuco D Standen, A Lanas, C Santibanez, P Soto, S Potthoff, R Soto, E Mercadal; China: L S Liu*, L X Jiang*, Beijing Hypertension League Institute and Fu Wai Hospital, Beijing
Q Chen, N Sun, J Wang, L Zhang, X Li, H Chen, Z Li, Y Shi, J Meng, D Wang, Z Liu, J Yan, W Zhang, Z Wan, Y Xu, X Li, L Wang, Q Fu, K Zhu, Y Wang, X Wang, F Wang, R Liu, R Zhao, K Sun, S Yue, Y Zhang, X Zhao, L Zhao, C Zhou, X Meng, A Liu, X Li, R Wu, R Xiao, X Zhang, G Wan, X Chen, Z Ge, T Zhou, Y Li, X Zhou, F Zhang; Colombia: LE Bautista*, Fundación Cardiovascular del Oriente Colombiano JP Casas, CA Morillo, E Ardilla, IA Arenas, M Lindarte, D Aristizabal; Croatia: Z Rumboldt*, University of Split M Rumboldt, V Carevic; Czech Republic: P Widimsky*, Charles University, Prague M Branny, P Gregor; Egypt: MS Khedr*, Suez Canal University, Cario MG Abdel-Aziz, S Abdel-Kader, MA Abdel-Moneim, F El-Demerdash, A El-Saiid, S Gharib, M Hassanin, F Abdel-Hamid Maklady, I Sadek; Germany: HJ Rupprecht*, T Wittlinger*, Oberarzt der II Medizinische Klinik P Schuster, A Schmidt, HR Ochs; Greece: N Karatzas*, A Pipilis*, Athens Hygeria SA
D Symeonides, K Karidis, TH Tsaknakis, K Kyfnidis; Guatemala: M Luna*, Unidad de Cirugia Cardiovascular de Guatemala AM Arroyo, G Sotomora, MA Rodas, L Velasquez, A Ovando; Hong Kong: J Sanderson*, Chinese University of Hong Kong, Prince of Wales Hospital WY Ma, S Chan; Hungary: M Keltai*, Hungary Institute of Cardiology Budapest F Szaboki, P Karpati, K Toth, S Timar, E Kalo, A Janosi, M Rusznak, D Lehoczky, J Tarjan, E Kiss, E Sitkei, P Valyi, I Edes; India: P Pais*, KS Reddy*, St. John’s Medical College and All India Institute of Medical Sciences PP Joshi, D Prabhakaran, D Xavier, A Roy, L Ramakrishnan; Iran: MRM Hasani*, SH Mirkhani*, Islamic Azad University, Tehran; Israel: D Halon*, B Lewis*, Lady Davis Carmel Hospital, Haifa; Italy: MG Franzosi*, G Tognoni*, Department of Cardiovascular Research, Instituto Mario Negri, Milano E Gardinale, M Villella, M Mennuni, F Saiu, G Pettinati, S Ciricugno, S Antonaci, L Carrieri, E Balli, D Bicego, MG DelleDonne, A Ottaviano, L Moretti, C Melloni, G Melandri, E Carbonieri, A Vetrano; Japan: M Hori*, Osaka University Graduate School of Medicine, Suita H Sato, K Fujii; Kenya: EN Ogola*, Nairobi Hospital P Wangai;
Kuwait: M Zubaid*, Kuwait University, Kuwait City W Rashed; Malaysia: CC Lang*, University Malaya, Faculty of Medicine, Kuala Lumpur WAW Ahmad, A Kadirvelu, R Zambahari; Mexico: MA Ramos-Corrales*, Hospital de Especialidades, Mexico City; Mozambique: A Damasceno*, Maputo General Hospital; Nepal: M R Pandey*, Nepal Heart Foundation G Baniya, A Sayami, M Kiratee, B Rawat, M Pandey, J Gurung; Netherlands: R Peters*, Acadmisch Medisch Centrum DCG Basart, PNA Bronzwaer, JA Heijmeriks, HR Michels, GMA Pop;
Nigeria: KK Akinroye*, Nigerian Heart Foundation; Pakistan: K Kazmi*, The Aga Khan University, Karachi NA Memon, SK Memon, S Nishtar, A Badar, MA Mattu, M Yakub, K Soomra, J Khatri, AMA Faruqui, SI Rasool, A Samad; Philippines: AL Dans*, Philippines General Hospital FQ Punzalan, MVC Villarruz, BT Mendoza, CS Recto III, BR Tamesis, V Mendoza, DJ Torres, DD Morales, I Ongtengco; Poland: A Budaj*, L Ceremuzynski*, Grochowski Hospital, Klinika Kardiologii CMKP, Warsawa S Stec, J Gorny, K Prochniewska, TK Urbanek, P Wojewoda, M Pawlowski, K Religa, R Klabisz, H Latocha, M Szpajer, K Cymerman, M Laniec, H Danielewicz, M Ogorek, D Kopcik, A Baranowska, A Kozlowski, M Blachowicz, A Jedrzejowski, T Waszyrowski, Z Zielinski, K Janik, M Tomzynski, M Mytnik, A Maziarz, G Rembelska, M Piepiorka, K Debkowska, T Krynski, B S Szczeklik, W Krasowski, M Rozwodowska, P Miekus, J Surwilo, S Malinowski, J Hybel, M Michalak, P Achremczyk, J Majchrzak, W S Korombel, M Dobrowolski, J Gessek; Portugal: J Morais*, University Hospital, Coronary Care Unit; Qatar: AA Gehani*, HA Hajar*, Hamad General Hospital MM Almowla, AA Omer; Russia: EG Volkova*, Ural State Medical Academy, Chelyabinsk SU Levashov, OM Filatova, UI Evchenko, GS Malkiman, NN Karaulovskaya; Seychelles: J Panovsky*, Victoria Hospital; Singapore: BA Johan*, National Heart Centre A Cheng, KS Ng, YL Lim, KH Neoh, KS Tan, LN Lum, Y Cheah; South Africa: P Commerford*, K Steyn*, University of Cape Town B Brown, F Martiz, P Raubenheimer, A Aboo, JD Marx, E Batiste, K Sliwa, P Sareli, C Zambiakides; Spain: V Valentin*, Universitari Dr Peset, Valencia J Ferriz, A Rovira, A Rodriguez-Llorian, E Cereijo, T Monzo, N Alonso, E Gomez-Martinez, A Lopez-Perez; Sri Lanka: S Mendis*, Peradeniya Teaching Hospital T Jayalath; Sultanate of Oman: ATA Hinai*, Sultan Qaboos University, Muscat MO Hassan;
Sweden: A Rosengren*, Sahlgrenska University Hospital/Ostra, Göteborg; Thailand: C Sitthi-Amorn*, Department of Medicine, Chulalongkorn University, Bangkok S Chaithiraphan, K Bhuripanyo, S Srimahachota, M Anukulwutipong, P Loothavorn, P Sritara, S Tanomsup, J Tantitham, P Tatsanavivat, T Yipinsoi, W Jintapakorn, W Puavilai, B Koanantakul, P Kasemsuwan, C Supanantareauk, C Peamsomboon, B Saejueng, K Jeamsomboon, A Sukontasup; United Arab Emirates: W Almahmeed*, Al-Jazeira and Central Hospitals, Abu Dhabi LO Abdelwareth, A Bokhari, NS Rao, S Bakir, AM Yusufali, E Hatou, Q Zaidi; UK: K Fox*, M Flather*, Royal Infirmary of Edinburgh, Edinburgh; USA: J Probstfield*, University of Washington, Seattle R Freeman, J Mathew, M Schweiger, W Johnson, E Ofili; Zimbabwe: J Chifamba*, University of Zimbabwe AJG Hakim.
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