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2020-10-16
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- INI - Artigos de Periódicos [3516]
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TUBERCULOSIS: FINDING A NEW POTENTIAL ANTIMYCOBACTERIUM DERIVATIVE IN A ALDEHYDE-ARYLHYDRAZONE-OXOQUINOLINE SERIES
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Resumen en ingles
Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis, which remains a serious public health problem. The emergence of resistant bacterial strains has continuously increased and new
treatment options are currently in need. In this work, we identified a new potential aldehyde–arylhydrazone–oxoquinoline derivative (4e) with interesting chemical structural features that may be important for designing new anti-TB agents. This 1-ethyl-N0 -[(1E)-(5-nitro-2-furyl)methylene]-4-oxo-1,4-dihydroquinoline-3-carbohydrazide (4e) presented an in vitro active profile against M. tuberculosis H37Rv strain (minimum inhibitory concentration, MIC = 6.25 lg/mL) better than other acylhydrazones described in the literature (MIC = 12.5 lg/mL) and close to other antitubercular agents currently on the market. The theoretical analysis showed the importance of several structural features that together with the 5-nitro-2-furyl group generated this active compound (4e). This new compound and the analysis of its molecular properties may be useful for designing new and more efficient antibacterial drugs.
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