Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/34618
Tipo de documento
ArtigoDireito Autoral
Acesso aberto
Data de embargo
2020-08-06
Coleções
- INI - Artigos de Periódicos [3488]
Metadata
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POST-CART PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY ERA IN A BRAZILIAN CENTER
Leukoencephalopathy
Progressive multifocal
Antiretroviral therapy
Highly active
Afiliação
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Federal University of Rio de Janeiro. Neurology Service. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Neurology Service. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Neurology Service. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratory of Viral Pathogenesis. Rio de Janeiro, RJ, Brasil.
Resumo em Inglês
Progressive multifocal leukoencephalopathy (PML) is lytic infection of oligodendrocytes caused by JC virus (JCV). While PML incidence in developing countries has decreased after the introduction of combination antiretroviral therapy (cART), data in developing countries is scarce and limited to few cohorts. We described the epidemiological and clinical profile of a group of Brazilian HIV infected patients with PML in the cART era. A total of 27 patients were included in the study. The median age at PML onset was 42 years (range: 27–67 years) and 18 (66.7%) were men. The median CD4 + T cell count at the time of diagnosis was 67cells/mm3 and the median HIV viral load was 27,000 copies/ml. Motor deficits were the most common early manifestations (44%). Seizures occurred in 37% of the patients and 9 (33.3%) had PML associated with immune reconstitution inflammatory syndrome (IRIS). Mortality was 33% and lower age at PML onset was associated with survival (p: 0.013). Our results are in accordance with previous published series of PML cases. Factors such as genetic background, regional JCV subtype differences, death from other diseases and underdiagnosis may explain the low prevalence of reported PML cases in developing countries.
Palavras-chave em inglês
HIVLeukoencephalopathy
Progressive multifocal
Antiretroviral therapy
Highly active
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