In vitro and in vivo models for monkeypox

Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil / Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Rodents Animal Facilities Complex. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.
Federal University of Uberlândia. Institute of Biomedical Sciences. Uberlândia, MG, Brazil.
Oswaldo Cruz Foundation. Aggeu Magalhães Institute. Department of Virology and Experimental Therapy. Recife, PE, Brazil.

Resumo em Inglês

The emergence and rapid spread outside of monkeypox virus (MPXV) to non-endemic areas has led to another global health emergency in the midst of the COVID-19 pandemic. The scientific community has sought to rapidly develop in vitro and in vivo models that could be applied in research with MPXV. In vitro models include two-dimensional (2D) cultures of immortalized cell lines or primary cells and three-dimensional (3D) cultures. In vitro models are considered cost-effective and can be done in highly controlled conditions; however, they do not always resemble physiological conditions. In this way, several in vivo models are being characterized to meet the growing demand for new studies related to MPXV. In this review, we summarize the main MPXV models that have already been developed and discuss how they can contribute to advance the understanding of its pathogenesis, replication, and transmission, as well as identifying antivirals to treat infected patients.

Palavras-chave em inglês

Virology
Monkeypox virus (MPXV)
Study viral infections
Cells
Virus strain
Viral cultivation

Editor

Cell Press

Referência

ROSA, Rafael Borges et al. n vitro and in vivo models for monkeypox. iScience, v. 26, n. 1, p. 1-44, Jan. 2023.

DOI

10.1016/j.isci.2022.105702

ISSN

2589-0042

Use este identificador para citar ou linkar para este item: https://www.arca.fiocruz.br/handle/icict/33932

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Direito Autoral

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