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THE POLYPHENOL-RICH EXTRACT FROM PSILOXYLON MAURITIANUM, AN ENDEMIC MEDICINAL PLANT FROM REUNION ISLAND, INHIBITS THE EARLY STAGES OF DENGUE AND ZIKA VIRUS INFECTION
Autor
Afiliación
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France. / Université Paris Diderot. Sorbonne Paris Cité. Paris, France.
Université Grenoble Alpes. INAC/CEA. Grenoble, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France. CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France. / Université Paris Diderot. Sorbonne Paris Cité. Paris, France.
Université Grenoble Alpes. INAC/CEA. Grenoble, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.
Institut Pasteur. Viral Genomics and Vaccination Unit. Paris, France.
Université de la Réunion. Unité Mixte Processus Infectieux en Milieu Insulaire Tropical. Plateforme Technologique CYROI. La Réunion, France.
Resumen en ingles
The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Medicinal plants have been widely used to treat various infectious diseases since millenaries. Several compounds extracted from plants exhibit potent effects against viruses in vitro, calling for further investigations regarding their efficacy as antiviral drugs. Here, we demonstrate that an extract from Psiloxylon mauritianum, an endemic medicinal plant from Reunion Island, inhibits the infection of ZIKV in vitro without exhibiting cytotoxic effects. The extract was active against different ZIKV African and Asian strains, including an epidemic one. Time-of-drug-addition assays revealed that the P. mauritianum extract interfered with the attachment of the viral particles to the host cells. Importantly, the P. mauritianum extract was also able to prevent the infection of human cells by four dengue virus serotypes. Due to its potency and ability to target ZIKV and DENV particles, P. mauritianum may be of value for identifying and characterizing antiviral compounds to fight medically-important flaviviruses.
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