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https://www.arca.fiocruz.br/handle/icict/33199
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ArtigoDireito Autoral
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2022-01-01
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- IOC - Artigos de Periódicos [12642]
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MICROVASCULAR EFFECTS OF CENTRALLY ACTING ANTIHYPERTENSIVE DRUGS IN SPONTANEOUSLY HYPERTENSIVE RATS
Clonidina
Imidazolinas
Capilaroscopia intravital
Moxonidina
Rilmenidina
Rato espontaneamente hipertensivo
Intravital capillaroscopy
Clonidine
SHR
Rilmenidine
Moxonidine
Imidazolines
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Louis Pasteur University. Faculty of Medicine. Laboratory of Neurobiology and Cardiovascular Pharmacology. Strasbourg, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Louis Pasteur University. Faculty of Medicine. Laboratory of Neurobiology and Cardiovascular Pharmacology. Strasbourg, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ. Brasil.
Resumo em Inglês
We investigated the effects of oral long-term antihypertensive
treatment using centrally acting sympathoinhibitory drugs on
capillary density in the skin, skeletal muscle, and heart in the
spontaneously hypertensive rat (SHR). Wistar Kyoto rats (WKY)
were used as normotensive control groups. Functional capillary
density was assessed using intravital fluorescence videomicroscopy
and structural capillary density with histochemical analysis. Groups
of 10 SHRs were orally treated over 28 days with clonidine
(0.1 mg kg21 d21), rilmenidine (1 mg kg21 d21), or moxonidine
(10 mg kg21 d21). A group of WKY was also treated with clonidine
(0.1 mg kg21 d21). Treatment with all antihypertensive drugs
induced a normalization of arterial pressure accompanied by a reversion
of functional capillary rarefaction in the skeletal muscle and
skin of SHR. Clonidine treatment also reduced arterial pressure and
increased functional capillary density in the skin and skeletal muscle
of WKY. Histochemical analysis showed that SHR had a lower
capillary to fiber ratio in the skeletal muscle (P , 0.0001), which was
normalized by all treatments. The capillary volume density to fiber
volume density ratio in the left ventricle of SHR was also significantly
reduced (P , 0.0001). However, myocardial capillary rarefaction was
not altered by the different treatments. In conclusion, the results
showed that long-term antihypertensive treatment with centrally
acting drugs enhanced tissue perfusion and reversed capillary rarefaction
in the skeletal muscle of SHRs.
Palavras-chave
Rarefação MicrovascularClonidina
Imidazolinas
Capilaroscopia intravital
Moxonidina
Rilmenidina
Rato espontaneamente hipertensivo
Palavras-chave em inglês
Capillary rarefactionIntravital capillaroscopy
Clonidine
SHR
Rilmenidine
Moxonidine
Imidazolines
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