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2020-05-08
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PERIPHERAL NEUROPATHY IN HTLV-I INFECTED INDIVIDUALS WITHOUT TROPICAL SPASTIC PARAPARESIS/HTLV-I-ASSOCIATED MYELOPATHY
Leite, A. C. C. B. et al. | Date Issued: 2004
Author
Leite, A. C. C. B.
Silva, M. T. T.
Alamy, A. H.
Afonso, C. R.
Lima, M. A.
Serpa, M. J. A.
Nascimento, O. J.
Araújo, A. Q. C.
Affilliation
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Fluminense Federal University. Service of Neurology. Niterói, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Fluminense Federal University. Service of Neurology. Niterói, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Centro de Referência em Neuroinfecções e HTLV. Rio de Janeiro, RJ, Brasil.
Abstract
Tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM) is the classical neurological manifestation of HTLV-I. Only a few studies have described isolated peripheral neuropathy (PN) among HTLV-I infected individuals. 335 infected individuals without TSP/HAM were evaluated for the presence of PN and 45 of them showed evidences of peripheral nervous system involvement. Of these 21 patients had isolated PN, defined by clinical and/or electrophysiological criteria. Sural nerve biopsies revealed inflammatory infiltrates in 2, axonal degeneration in 2 and segmental demyelination in 1. Therefore, peripheral neuropathy can be found as an isolated manifestation of HTLV-I infection. We conclude that HTLV-I infection should be investigated in patients with PN of unknown origin.
Keywords
HTLV-I
Peripheral neuropathy
TSP/HAM
 
Publisher
Springer Verlag
Citation
LEITE, Ana C. C. L. et al. Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis/HTLV-I-associated myelopathy. Journal of Neurology, v. 251, n. 7, p. 877-881, July 2004.
DOI
10.1007/s00415-004-0455-7
ISSN
0340-5354