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https://www.arca.fiocruz.br/handle/icict/32985
DETECTION OF ANTI-TRYPANOSOMA CRUZI ANTIBODIES BY CHIMERIC ANTIGENS IN CHRONIC CHAGAS DISEASE-INDIVIDUALS FROM ENDEMIC SOUTH AMERICAN COUNTRIES
Chagas disease
Antigens
Chimeric proteins
Diagnostics
Brazil
Autor(es)
Afiliação
Faculty of Technology and Sciences of Bahia. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology and Legal Medicine. Salvador, BA, Brazil / Yale University. School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States of America.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Molecular Biology Institute of Paraná. Curitiba, PR, Brazil.
Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology and Legal Medicine. Salvador, BA, Brazil / Yale University. School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, United States of America.
Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Institute for Research on Genetic Engineering and Molecular Biology “Dr Héctor Torres”. Laboratory of Molecular Biology of Chagas Disease. Buenos Aires, Argentina.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Resumo em Inglês
Laboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctuate depending on the antigenic matrices and the local strains of T. cruzi in different geographical settings. The use of antigenic matrices based on chimeric proteins can solve these limitations. Here, we evaluated the diagnostic performance of two chimeric T. cruzi antigens (IBMP-8.1 and -8.4) to diagnose chronic Chagas disease in individuals from endemic South American countries.
Palavras-chave em inglês
Trypanosoma cruziChagas disease
Antigens
Chimeric proteins
Diagnostics
Brazil
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