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ArtículoDerechos de autor
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Fecha del embargo
2020-05-03
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- INI - Artigos de Periódicos [3488]
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CREUTZFELDT-JAKOB DISEASE AND INCLUSION BODY MYOSITIS: ABUNDANT DISEASE-ASSOCIATED PRION PROTEIN IN MUSCLE.
Autor
Afiliación
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria / National Institute of Psychiatry and Neurology. Budapest, Hungary.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
Federal University of Rio de Janeiro. School of Medicine. Department of Pathology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Department of Neurology. Rio de Janeiro, RJ, Brazil.
Federal University of São Paulo. School of Medicine. Department of Neurology. São Paulo, SP, Brazil.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland.
University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
Federal University of Rio de Janeiro. School of Medicine. Department of Pathology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. School of Medicine. Department of Neurology. Rio de Janeiro, RJ, Brazil.
Federal University of São Paulo. School of Medicine. Department of Neurology. São Paulo, SP, Brazil.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland.
University Hospital of Zürich. Institute of Neuropathology. Zürich, Switzerland.
University of Vienna. Institute of Neurology. Vienna, Austria / Austrian Reference Centre for Human Prion Diseases. Vienna, Austria.
Resumen en ingles
Pathological prion protein (PrPSc) is the hallmark ofprion diseases affecting primarily the central nervous sys-tem. Using immunohistochemistry, paraffin-embeddedtissue blot, and Western blot, we demonstrated abundant PrPScin the muscle of a patient with sporadicCreutzfeldt–Jakob disease and inclusion body myositis. Extraneural PrPC-PrPScconversion in Creutzfeldt–Jakobdisease appears to become prominent when PrPCis abun-dantly available as substrate, as in inclusion body myosi-tis muscle.
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