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https://www.arca.fiocruz.br/handle/icict/32313
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ArticleCopyright
Open access
Embargo date
2020-03-01
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- INI - Artigos de Periódicos [3460]
- PE - IAM - Artigos de Periódicos [1085]
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FAMILIAR BARRIERS STILL UNRESOLVED: A PERSPECTIVE ON THE ZIKA VIRUS OUTBREAK RESEARCH RESPONSE
ZIKAlliance Consortium - Renata Rabello - Fundação Oswaldo Cruz. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
Affilliation
Erasmus MC. Rotterdam, Netherlands.
Aix-Marseille University. Unité des Virus Émergents. Marseille, France.
Heidelberg University Hospital. Section Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.
Aix-Marseille University. Unité des Virus Émergents. Marseille, France.
Heidelberg University Hospital. Section Clinical Tropical Medicine. Department of Infectious Diseases. Heidelberg, Germany.
Abstract
Research is an important component of an effective response to the increasing frequency of widespread infectious disease outbreaks. In turn, the ability to do such studies relies on willingness of partners in different regions to collaborate and the capacity to mount a rapid research response. The EU-funded ZIKAlliance Consortium has initiated a multicountry epidemiological, clinical, and laboratory research agenda to determine the incidence, risk factors, and outcomes of Zika virus infection in pregnant women and their children. We reviewed the timeline of patient cohort initiation in relation to the Zika virus epidemic and mapped key events regarding funding, regulatory approvals, and site preparation during this timeline. We then assessed barriers and delays that the international research team experienced through a systematic telephone interview. We have identified three major bottlenecks in the implementation of a swift response: the absence of a timeline for the funding process, delays in regulatory and ethical approval, and the challenging logistics of laboratory support, including diagnostics. These bottlenecks illustrate the clear and urgent need for implementing a strong and permanent global emerging infectious diseases research capacity that has structured funding, enables long-term partnerships, and develops basic clinical and laboratorial research and a response infrastructure that is ready to deploy.
Publisher
Elsevier
Citation
KOOPMANS, Marion et al. Familiar barriers still unresolved: a perspective on the Zika virus outbreak research response. Lancet Infectious Diseases, v. 19, p. 59-62, Feb. 2019.DOI
10.1016/S1473-3099(18)30497-3ISSN
1473-3099Notes
ZIKAlliance Consortium - Patricia Brasil - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.ZIKAlliance Consortium - Renata Rabello - Fundação Oswaldo Cruz. Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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