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ANENPI: IDENTIFICATION AND ANNOTATION OF ANALOGOUS ENZYMES
Otto, Thomas D. et al. | Date Issued: 2008
Author
Otto, Thomas D.
Guimarães, Ana Carolina R.
Degrave, Wim M.
Miranda, Antonio B. de
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil / Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ. Brasil.
Abstract
Enzymes are responsible for the catalysis of the biochemical reactions in metabolic pathways. Analogous enzymes are able to catalyze the same reactions, but they present no significant sequence similarity at the primary level, and possibly different tertiary structures as well. They are thought to have arisen as the result of independent evolutionary events. A detailed study of analogous enzymes may reveal new catalytic mechanisms, add information about the origin and evolution of biochemical pathways and disclose potential targets for drug development.
Keywords in Portuguese
Enzimas análogas
Identificação
Pipeline de Enzimas Análogas
AnEnPi
 
Keywords
Analogous enzymes
Identification
Analogous Enzyme Pipeline
AnEnPi
 
Publisher
BMC
Citation
OTTO, Thomas D. et al. AnEnPi: identification and annotation of analogous enzymes. BMC Bioinformatics, v. 9, n. 544, 9p, Dec. 2008.
DOI
10.1186/1471-2105-9-544
ISSN
1471-2105