Por favor, use este identificador para citar o enlazar este ítem:
https://www.arca.fiocruz.br/handle/icict/31451
Tipo
ArtículoDerechos de autor
Acceso abierto
Colecciones
Metadatos
Mostrar el registro completo del ítem
UNDERSTANDING ASTHMA PHENOTYPES: THE WORLD ASTHMA PHENOTYPES (WASP) INTERNATIONAL COLLABORATION
Fenotipo
Biomarcadores
Fatores de risco
Tratamento
Prevenção
Protocolo de pesquisa
Colaboração
Phenotypes
Biomarkers
Risk factors
Treatment
Prevention
Protocols
Collaboration
Autor
Pembrey, Lucy
Barreto, Maurício Lima
Douwes, Jeroen
Cooper, Philip
Henderson, John
Mpairwe, Harriet
Garcia, Cristina Ardura
Chico, Martha
Brooks, Collin
Cruz Filho, Alvaro Augusto Souza da
Elliott, Alison M.
Figueiredo, Camila Alexandrina Viana de
Langan, Sinéad M.
Nassanga, Beatrice
Ring, Susan
Rodrigues, Laura Cunha
Pearce, Neil
Barreto, Maurício Lima
Douwes, Jeroen
Cooper, Philip
Henderson, John
Mpairwe, Harriet
Garcia, Cristina Ardura
Chico, Martha
Brooks, Collin
Cruz Filho, Alvaro Augusto Souza da
Elliott, Alison M.
Figueiredo, Camila Alexandrina Viana de
Langan, Sinéad M.
Nassanga, Beatrice
Ring, Susan
Rodrigues, Laura Cunha
Pearce, Neil
Afiliación
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Massey University. Centre for Public Health Research Wellington. New Zealand.
St George’s University of London. London, UK / Universidad Internacional del Ecuador. Quito, Ecuador / Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
Massey University. Centre for Public Health Research Wellington. New Zealand.
Federal University of Bahia. The Programme for Control of Asthma and Allergic Rhinitis. Salvador, BA, Brazil / Federal University of Bahia. Institute for Health Sciences. Salvador, BA, Brazil.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
London School of Hygiene and Tropical Medicine. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Massey University. Centre for Public Health Research Wellington. New Zealand.
St George’s University of London. London, UK / Universidad Internacional del Ecuador. Quito, Ecuador / Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
Fundacion Ecuatoriana Para Investigacion en Salud. Quito, Ecuador.
Massey University. Centre for Public Health Research Wellington. New Zealand.
Federal University of Bahia. The Programme for Control of Asthma and Allergic Rhinitis. Salvador, BA, Brazil / Federal University of Bahia. Institute for Health Sciences. Salvador, BA, Brazil.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
Uganda Virus Research Institute. Uganda Research Unit on AIDS. Medical Research Council. Entebbe, Uganda.
University of Bristol. Bristol Medical School. Population Health Sciences. Bristol, UK.
London School of Hygiene and Tropical Medicine. London, United Kingdom.
London School of Hygiene and Tropical Medicine. London, United Kingdom / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Resumen en ingles
The World Asthma Phenotypes (WASP) study started in 2016 and has been conducted in five centres, in the UK, New Zealand, Brazil, Ecuador and Uganda. The objectives of this study are to combine detailed biomarker and clinical information in order to 1) better understand and characterise asthma phenotypes in high-income countries (HICs) and low and middle-income countries (LMICs), and in high and low prevalence centres; 2) compare phenotype characteristics, including clinical severity; 3) assess the risk factors for each phenotype; and 4) assess how the distribution of phenotypes differs between high prevalence and low prevalence centres. Here we present the rationale and protocol for the WASP study to enable other centres around the world to carry out similar analyses using a standardised protocol. Large collaborative and integrative studies like this are essential to further our understanding of asthma phenotypes. The findings of this study will help elucidate the aetiological mechanisms of asthma and might potentially identify new causes and guide the development of new treatments, thereby enabling better management and prevention of asthma in both HICs and LMICs.
Palabras clave en portugues
AsmaFenotipo
Biomarcadores
Fatores de risco
Tratamento
Prevenção
Protocolo de pesquisa
Colaboração
Palabras clave en ingles
AsthmaPhenotypes
Biomarkers
Risk factors
Treatment
Prevention
Protocols
Collaboration
Compartir