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AFRICAN BIOGEOGRAPHICAL ANCESTRY, ATOPIC AND NON-ATOPIC ASTHMA AND ATOPY: A STUDY IN LATIN AMERICAN CHILDREN
Silva, Thiago Magalhães da et al. | Date Issued: 2019
Author
Silva, Thiago Magalhães da
Fiaccone, Rosemeire Leovigildo
Kehdy, Fernanda de Souza Gomes
Santos, Eduardo Tarazona
Rodrigues, Laura Cunha
Costa, Gustavo Nunes de Oliveira
Figueiredo, Camila Alexandrina de
Santos, Darci Neves dos
Feitosa, Caroline Alves
Fattore, Gisel Lorena
Santos, Leticia Marques dos
Neves, Neuza Maria Alcantara
Cruz, Álvaro Augusto
Barreto, Maurício Lima
Affilliation
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Jequié, BA, Brasil.
Universidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brasil.
London School of Hygiene and Tropical Medicine. Faculty of Epidemiology. Department of Infectious Disease Epidemiology. London, United Kingdom.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Universidad Nacional de Lanús. Departamento de Salud Comunitaria. Buenos Aires, Argentina.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.
Federal University of Bahia. School of Medicine. ProAR-Center of Excellence in Asthma. Salvador, BA, Brazil.
Federal University of Bahia. Institute of Collective Health. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Centro de Integração de Dados e Conhecimento para a Saúde. Salvador, BA, Brasil.
Abstract
Genetic variants underlying African ancestry have been suggested be implicated in the ethnic-racial inequalities reported for asthma and allergies. Objectives: To investigate the association between individual African ancestry and asthma symptoms, atopic and non-atopic asthma, and atopy in children. Methods: A cross-sectional study encompassing 1190 individuals was conducted. African biogeographic ancestry was estimated using 370 539 genome-wide SNPs. Serum levels of specific IgE were measured, and skin prick test (SPT) performed for the most common local aeroallergens. Information on asthma symptoms was obtained by applying the International Study of Allergy and Asthma in Childhood questionnaire. The associations between the proportion of individual African ancestry and the outcomes investigated were analyzed through multivariate models adjusted for socio-environmental variables, infections markers, and psychosocial factors. Results: Each 20% increase in the proportion of African ancestry was negatively associated with SPT reactivity (OR: 0.79, 95%CI: 0.66-0.96) and positively associated with asthma symptoms in non-atopic individuals (OR: 1.40, 95%CI: 1.03-1.89). We estimated that socioeconomic status and number of infections mediated 28.4% of the effect of African ancestry on SPT reactivity, while 20.2% of the effect on non-atopic asthma was explained by socioeconomic status and behavioral problems in children. Conclusions: The negative association observed between African ancestry and atopy is most probably explained by unobserved environmental or social factors that covariate with ancestry. For non-atopic asthma, in turn, putative genetic variants of risk underlying African ancestry may play some role.
Keywords in Portuguese
Alergia
Asma
Ascendência biogeográfica
Mediação
Desigualdades raciais
 
Keywords
Allergy
Asthma
Biogeographical ancestry
Mediation
Racial inequalities
 
Publisher
Wiley
Citation
SILVA, T. M. et al. African biogeographical ancestry, atopic and non-atopic asthma and atopy: A study in Latin American children. Pediatric Pulmonology, v. 54, p. 125–132, 2019.
DOI
10.1002/ppul.24213
ISSN
8755-6863