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BIOMARKERS AND IMMUNOPROFILES ASSOCIATED WITH FETAL ABNORMALITIES OF ZIKV-POSITIVE PREGNANCIES
Suan-Sin, Foo et al. | Date Issued: 2018
Author
Suan-Sin, Foo
Weiqiang, Chen
Yen, Chan
Wai-Suet, Lee
Shin-Ae, Lee
Genhong, Cheng
Nielsen-Saines, Karin
Brasil, Patrícia
Jung, Jae U.
Affilliation
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Obstetrics and Gynecology. Division of Maternal-Fetal Medicine. Los Angeles, CA, USA.
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA / Griffith University, Gold Coast. Institute for Glycomics. Southport, Queensland, Australia.
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
University of California, Los Angeles. David Geffen School of Medicine. Department of Microbiology and Molecular Genetics. Los Angeles, CA, USA.
University of California, Los Angeles. David Geffen School of Medicine. Marion Davies Children’s Health Center. Division of Pediatric Infectious Diseases. Los Angeles, CA, USA.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.
University of Southern California. Keck School of Medicine. Zilkha Neurogenetic Institute. Department of Molecular Microbiology and Immunology. Los Angeles, CA, USA.
Abstract
BACKGROUND. An intricate fetal-maternal immune crosstalk during pregnancy is essential for a healthy birth. Hence, the infection-induced alterations of maternal immunity often lead to adverse outcomes for mother and/or child. The emergence of Zika virus (ZIKV) infection in pregnant women has been associated with more than 3,000 cases of microcephaly and nervous system malformations. METHODS. To explore the potential correlation of ZIKV-induced alteration of maternal immunity with fetal abnormalities, we performed extensive sera immunoprofiling of 74 pregnant women: 30 symptomatic ZIKV+ pregnant patients and 30 healthy pregnant controls in ZIKV-endemic Rio de Janeiro, along with 14 healthy pregnant controls in non-endemic Los Angeles. RESULTS. Extensive multiplexing analysis of 69 cytokines revealed that CXCL10, CCL2, and CCL8 chemokines were specifically associated with symptomatic ZIKV+ infection during pregnancy, and distinct immunoprofiles were detected at different trimesters in ZIKV-infected pregnant women. Intriguingly, the high CCL2 level and its inverse correlation with CD163, TNFRSF1A, and CCL22 levels was apparently associated with ZIKV-induced abnormal birth. CONCLUSION. Our findings provide insights into the alteration of ZIKV-elicited maternal immunity, serving as a potential clinical biomarker platform.
Keywords
Biomarkers
Immunoprofiles
Fetal abnormalities
ZIKV-positive pregnancies
 
Citation
SUAN-SIN, Foo et al. Biomarkers and immunoprofiles associated with fetal abnormalities of ZIKV-positive pregnancies. JCI Insight, v. 3, n. 21, p. 1-11, 2018.
DOI
10.1172/jci.insight.124152
ISSN
2379-3708