Use este identificador para citar ou linkar para este item:
https://www.arca.fiocruz.br/handle/icict/30772
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2050-01-01
Coleções
Metadata
Mostrar registro completo
ANTIRETROVIRAL DRUG RESISTANCE IN A RESPONDENT-DRIVEN SAMPLE OF HIV-INFECTED MEN WHO HAVE SEX WITH MEN IN BRAZIL
Men who have sex with men
Respondent-driven sampling
Brazil
Antiretroviral resistance
Substituição de aminoácidos
Anti-retrovirais / farmacologia
Anti-retrovirais / uso terapêutico
Brasil
Análise de Cluster
Coleção de dados
Resistência a Medicamentos Virais
Genótipo
Infecções por HIV / fármaco terapia
Infecções por HIV / virologia
Protease do HIV / genética
Transcriptase reversa do HIV / genética
HIV-1 / classificação
HIV-1 / efeitos de drogas
HIV-1 / genética
HIV-1 / isolamento e purificação
Homossexualidade masculina
Humanos
Masculino
Dados de Sequencia Molecular
Mutação, Missense
Análise de Sequência, DNA
População urbana
Substâncias
Autor(es)
Bermúdez-Aza, Elkin Hernan
Kerr, Ligia Regina Franco Sansigolo
Kendall, Carl
Pinho, Adriana Araujo
Mello, Maeve Brito de
Mota, Rosa Salani
Guimarães, Mark Drew Crosland
Alencar, Cecilia Salete
Brito, Ana Maria de
Dourado, Ines Costa
Batista, Sonia Maria da
Abreu, Fabiano
Oliveira, Lisangela Cristina de
Moraes, Adão Souza de
Benzaken, Adele Schwartz
Merchan-Hamann, Edgar
Freitas, Gisele Maria Brandão de
McFarland, Willi
Albuquerque, Elizabeth
Rutherford, George W.
Sabino, Ester
Kerr, Ligia Regina Franco Sansigolo
Kendall, Carl
Pinho, Adriana Araujo
Mello, Maeve Brito de
Mota, Rosa Salani
Guimarães, Mark Drew Crosland
Alencar, Cecilia Salete
Brito, Ana Maria de
Dourado, Ines Costa
Batista, Sonia Maria da
Abreu, Fabiano
Oliveira, Lisangela Cristina de
Moraes, Adão Souza de
Benzaken, Adele Schwartz
Merchan-Hamann, Edgar
Freitas, Gisele Maria Brandão de
McFarland, Willi
Albuquerque, Elizabeth
Rutherford, George W.
Sabino, Ester
Resumo em Inglês
Background: There are few studies on HIV subtypes and primary
and secondary antiretroviral drug resistance (ADR) in communityrecruited
samples in Brazil. We analyzed HIV clade diversity and
prevalence of mutations associated with ADR in men who have sex
with men in all five regions of Brazil.
Methods: Using respondent-driven sampling, we recruited 3515
men who have sex with men in nine cities: 299 (9.5%) were HIVpositive;
143 subjects had adequate genotyping and epidemiologic
data. Forty-four (30.8%) subjects were antiretroviral therapyexperienced
(AE) and 99 (69.2%) antiretroviral therapy-naı¨ve
(AN). We sequenced the reverse transcriptase and protease regions
of the virus and analyzed them for drug resistant mutations using
World Health Organization guidelines.
Results: The most common subtypes were B (81.8%), C (7.7%),
and recombinant forms (6.9%). The overall prevalence of primary ADR resistance was 21.4% (i.e. among the AN) and secondary ADR
was 35.8% (i.e. among the AE). The prevalence of resistance to
protease inhibitors was 3.9% (AN) and 4.4% (AE); to nucleoside
reverse transcriptase inhibitors 15.0% (AN) and 31.0% (AE) and to
nonnucleoside reverse transcriptase inhibitors 5.5% (AN) and 13.2%
(AE). The most common resistance mutation for nucleoside reverse
transcriptase inhibitors was 184V (17 cases) and for nonnucleoside
reverse transcriptase inhibitors 103N (16 cases).
Conclusions: Our data suggest a high level of both primary and
secondary ADR in men who have sex with men in Brazil. Additional
studies are needed to identify the correlates and causes of
antiretroviral therapy resistance to limit the development of resistance
among those in care and the transmission of resistant strains in the
wider epidemic.
Palavras-chave em inglês
HIV-1Men who have sex with men
Respondent-driven sampling
Brazil
Antiretroviral resistance
DeCS
AdultoSubstituição de aminoácidos
Anti-retrovirais / farmacologia
Anti-retrovirais / uso terapêutico
Brasil
Análise de Cluster
Coleção de dados
Resistência a Medicamentos Virais
Genótipo
Infecções por HIV / fármaco terapia
Infecções por HIV / virologia
Protease do HIV / genética
Transcriptase reversa do HIV / genética
HIV-1 / classificação
HIV-1 / efeitos de drogas
HIV-1 / genética
HIV-1 / isolamento e purificação
Homossexualidade masculina
Humanos
Masculino
Dados de Sequencia Molecular
Mutação, Missense
Análise de Sequência, DNA
População urbana
Substâncias
Compartilhar