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2020-01-01
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EFFECTS OF INTERACTIONS BETWEEN APOE POLYMORPHISMS, ALCOHOL CONSUMPTION AND OBESITY ON AGE-RELATED TRENDS OF BLOOD PRESSURE LEVELS IN POSTMENOPAUSAL WOMEN: THE BAMBUÌ COHORT STUDY OF AGING (1997-2008)
Apolipoproteína E
Pressão sanguínea
Obesidade
Menopausa
Afiliación
Institute of Biomedical Technologies. National Research Council.Milan, Italy.
Universidade Federal do Rio Grande do Sul. Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.
Universidade Federal do Rio Grande do Sul. Universidade do Vale dos Sinos. Porto Alegre, RS, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasil.
Resumen en ingles
Objectives: To evaluate the effects of interactions between ApoE genotypes, alcohol consumption and obesity on the age-related trends of blood pressure (BP) levels in postmenopausal women. Study design: A population-based prospective cohort study of all residents in Bambuì, south-eastern Brazil, aged 60 years or older. Repeated BP measurements were obtained in four waves from 851 women who underwent ApoE genotyping at baseline (88.3% of those enrolled), and multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, while accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. The few measurements (2.1%) made during hormone replacement therapy were excluded from the analysis. Results: Alcohol consumption was associated with high levels of systolic and diastolic BP in an age × genotype-dependent manner only in the non-obese women (BMI < 27 kg/m2). Among those with the ɛ3/3 genotype, the differences in systolic and diastolic levels between drinkers and non-drinkers estimated at the age of 60 years were respectively 13.7 mmHg (p = 0.022) and 10.7 mmHg (p = 0.002), and disappeared in the older age groups, in which drinking was associated with systolic/diastolic hypertension if the non-obese women were ɛ4 carriers.
Conclusion: In non-obese postmenopausal women, alcohol consumption is associated with systolic and diastolic hypertension early in those with the ɛ3/3 ApoE genotype, and late in ɛ4 carriers. We hypothesize the mediation of androgen hormones and the influence of ApoE genotypes on age at natural menopause. A better understanding of these mechanisms may guide better preventive choices.
Palabras clave en portugues
Consumo de álcoolApolipoproteína E
Pressão sanguínea
Obesidade
Menopausa
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