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- IOC - Artigos de Periódicos [12642]
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COMPLETE GENOME SEQUENCE OF THE MARINE FISH PATHOGEN VIBRIO ANGUILLARUM HARBORING THE PJM1 VIRULENCE PLASMID AND GENOMIC COMPARISON WITH OTHER VIRULENT STRAINS OF V. ANGUILLARUM AND V. ORDALII
Vibrio anguillarum
V. ordalii
Patógenos
Peixes Marinhos
Plasmídeo de Virulência pJM1
Vibrio anguillarum
V. ordalii
Marine Fish
JM1 Virulence Plasmid
Marine Fish Pathogen
Autor(es)
Afiliação
Oregon Health and Science University. Department of Molecular Microbiology and Immunology. Portland, Oregon, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Oregon Health and Science University. Department of Molecular Microbiology and Immunology. Portland, Oregon, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.
Oregon Health and Science University. Department of Molecular Microbiology and Immunology. Portland, Oregon, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Oregon Health and Science University. Department of Molecular Microbiology and Immunology. Portland, Oregon, USA.
Universidade Federal do Rio de Janeiro. Instituto de Biologia. Rio de Janeiro, RJ, Brasil.
Oregon Health and Science University. Department of Molecular Microbiology and Immunology. Portland, Oregon, USA.
Resumo em Inglês
We dissected the complete genome sequence of the O1 serotype strain Vibrio anguillarum 775(pJM1) and determined the draft genomic sequences of plasmidless strains of serotype O1 (strain 96F) and O2β (strain RV22) and V. ordalii. All strains harbor two chromosomes, but 775 also harbors the virulence plasmid pJM1, which carries the anguibactin-producing and cognate transport genes, one of the main virulence factors of V. anguillarum. Genomic analysis identified eight genomic islands in chromosome 1 of V. anguillarum 775(pJM1) and two in chromosome 2. Some of them carried potential virulence genes for the biosynthesis of O antigens, hemolysins, and exonucleases as well as others for sugar transport and metabolism. The majority of genes for essential cell functions and pathogenicity are located on chromosome 1. In contrast, chromosome 2 contains a larger fraction (59%) of hypothetical genes than does chromosome 1 (42%). Chromosome 2 also harbors a superintegron, as well as host "addiction" genes that are typically found on plasmids. Unique distinctive properties include homologues of type III secretion system genes in 96F, homologues of V. cholerae zot and ace toxin genes in RV22, and the biofilm formation syp genes in V. ordalii. Mobile genetic elements, some of them possibly originated in the pJM1 plasmid, were very abundant in 775, resulting in the silencing of specific genes, with only few insertions in the 96F and RV22 chromosomes.
Palavras-chave
Sequência do genomaVibrio anguillarum
V. ordalii
Patógenos
Peixes Marinhos
Plasmídeo de Virulência pJM1
Palavras-chave em inglês
Genome SequenceVibrio anguillarum
V. ordalii
Marine Fish
JM1 Virulence Plasmid
Marine Fish Pathogen
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