Autor
Afiliación
Resumen en ingles
Background: Neutralizing antibodies provide markers for vaccine-induced protective immunity in many viral infections. By
analogy, HIV-1 neutralizing antibodies induced by immunization may well predict vaccine effectiveness. Assessment of
neutralizing antibodies is therefore of primary importance, but is hampered by the fact that we do not know which assay(s)
can provide measures of protective immunity. An international collaboration (NeutNet) involving 18 different laboratories
previously compared different assays using monoclonal antibodies (mAbs) and soluble CD4 (Phase I study).
Editor
Public Library of Science
Referencia
HEYNDRICKX, Leo; et al. International Network for Comparison of HIV Neutralization Assays: The NeutNet Report II. Plos One, v.7, n.5, e36438, 11p, May 2012.
ISSN
1932-6203
Notas
AUTHORS: Leo Heyndrickx5*, Alan Heath4, Enas Sheik-Khalil3, Jose Alcami1, Vera Bongertz2, Marianne Jansson6,
Mauro Malnati7, David Montefiori8, Christiane Moog9, Lynn Morris10, Saladin Osmanov11,
Victoria Polonis12, Meghna Ramaswamy4, Quentin Sattentau13, Monica Tolazzi14,
Hanneke Schuitemaker15, Betty Willems5, Terri Wrin16, Eva Maria Fenyo¨ 3, Gabriella Scarlatti14 --- AFFILIATIONS - Unidad de Immunopatologia del SIDA, Instituto de Salud Carlos III, Madrid, Spain, 2 Laboratory of AIDS and Molecular Immunology, Fundac¸a˜o Oswaldo Cruz, Rio de
Janeiro, Brazil, 3 Department of Laboratory Medicine, University of Lund, Lund, Sweden, 4 National Institute for Biological Standards and Control, Potters Bar,
Hertfordshire, United Kingdom, 5 Virology Unit, Biomedical Department, Institute of Tropical Medicine, Antwerp, Belgium, 6 Department of Microbiology, Tumor and Cell
Biology, Karolinska Institutet, Stockholm, Sweden, 7 Unit of Human Virology, San Raffaele Scientific Institute, Milan, Italy, 8 Duke University Medical Center, Durham, North
Carolina, United States of America, 9 Pathoge´nie des infections persistantes, University Louis Pasteur, Strasbourg, France, 10 National Institute for Communicable
Diseases, Johannesburg, South Africa, 11 WHO-UNAIDS HIV Vaccine Initiative, World Health Organization, Geneva, Switzerland, 12 Department of Vaccine Research, Henry
Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, United States of America, 13 The Sir William Dunn School of Pathology, The University
of Oxford, Oxford, United Kingdom, 14 Viral Evolution and Transmission Unit, San Raffaele Scientific Institute, Milan, Italy, 15 Department of Experimental Immunology,
Academic Medical Center at the University of Amsterdam, Amsterdam, The Netherlands, 16 Monogram Biosciences, San Francisco, California, United States of America.
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