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https://www.arca.fiocruz.br/handle/icict/29684
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2100-01-01
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INNATE SENSING OF MALARIA PARASITES
Autor(es)
Afiliação
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brasil.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA.
Division of Infectious Diseases and Immunology. University of Massachusetts Medical School. Worcester, MA, USA / Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, Brasil.
Resumo em Inglês
Innate immune receptors have a key role in immune surveillance by sensing microorganisms and initiating protective immune responses. However, the innate immune system is a classic 'double-edged sword' that can overreact to pathogens, which can have deleterious effects and lead to clinical manifestations. Recent studies have unveiled the complexity of innate immune receptors that function as sensors of Plasmodium spp. in the vertebrate host. This Review highlights the cellular and molecular mechanisms by which Plasmodium infection is sensed by different families of innate immune receptors. We also discuss how these events mediate both host resistance to infection and the pathogenesis of malaria.
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