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PRE-CART ELEVATION OF CRP AND CD4+ T-CELL IMMUNE ACTIVATION ASSOCIATED WITH HIV CLINICAL PROGRESSION IN A MULTINATIONAL CASE-COHORT STUDY
Balagopal, Ashwin et al. | Date Issued: 2015
Author
Balagopal, Ashwin
Asmuth, David M
Yang, Wei-Teng
Campbell, Thomas B.
Gupte, Nikhil
Smeaton, Laura
Kanyama, Cecilia
Grinsztejn, Beatriz
Santos, Breno
Supparatpinyo, Khuanchai
Badal-Faesen, Sharlaa
Lama, Javier R.
Lalloo, Umesh G.
Zulu, Fatima
Pawar, Jyoti S.
Riviere, Cynthia
Kumarasamy, Nagalingeswaran
Hakim, James
Li, Xiao-Dong
Pollard, Richard B.
Semba, Richard D.
Thomas, David L.
Bollinger, Robert C.
Gupta, Amita
ACTG PEARLS Study team
NWCS 319 Study team
Affilliation
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
University of California Davis. Department of Medicine. Sacramento, CA, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
University of Colorado Denver. Aurora, CO, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
Harvard School of Public Health. Boston, MA, USA.
University of North Carolina Project. Lilongwe, Malawi.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil.
Hospital Nossa Senhora da Conceição. Porto Alegre, Brasil.
Chiang Mai University. Chiang Mai, Thailand.
University of Witwatersrand. Department of Medicine. Johannesburg, South Africa.
IMPACTA PERU Clinical Trials Unit. Asociacion Civil Impacta Salud y Educacion. Lima, Peru.
University of KwaZulu Natal. Nelson R Mandela School of Medicine. Durban, South Africa.
Malawi College of Medicine-Johns Hopkins Research Project. Kachere Rehabilitation Centre. Blantyre, Malawi.
National AIDS Research Institute. Pune, India.
Les Centres GHESKIO. Port-au-Prince, Haiti.
YR Gaitonde Center for AIDS Research and Education. Chennai, India.
University of Zimbabwe. Harare, Zimbabwe.
University of California Davis. Department of Medicine. Sacramento, CA, USA.
Johns Hopkins University. Department of Ophthalmology. Baltimore, MD, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
Johns Hopkins University School of Medicine. Department of Medicine. Baltimore, USA.
Abstract
Despite the success of combination antiretroviral therapy (cART), a subset of HIV-infected patients who initiate cART develop early clinical progression to AIDS; therefore, some cART initiators are not fully benefitted by cART. Immune activation pre-cART may predict clinical progression in cART initiators.
Keywords
Immune activation
Global HIV
cART clinical outcomes
C-Reactive protein
T-cell activation
 
Citation
BALAGOPAL, Ashwin. et al. Pre-cART elevation of CRP and CD4+ T-Cell immune activation associated with HIV clinical progression in a multinational case-cohort study. Journal of Acquired Immune Deficiency Syndromes, v. 70, n. 2, p. 163-171, 2015.
DOI
10.1097/QAI.0000000000000696
ISSN
1525-4135